Calcium signaling in neurodegeneration
<p>Abstract</p> <p>Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular level of the versatility of this ion has made overwhe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-05-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/4/1/20 |
| _version_ | 1828258446774894592 |
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| author | Dreses-Werringloer Ute Marambaud Philippe Vingtdeux Valérie |
| author_facet | Dreses-Werringloer Ute Marambaud Philippe Vingtdeux Valérie |
| author_sort | Dreses-Werringloer Ute |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular level of the versatility of this ion has made overwhelming progress in the past several years and has been extensively reviewed. In the brain, calcium is fundamental in the control of synaptic activity and memory formation, a process that leads to the activation of specific calcium-dependent signal transduction pathways and implicates key protein effectors, such as CaMKs, MAPK/ERKs, and CREB. Properly controlled homeostasis of calcium signaling not only supports normal brain physiology but also maintains neuronal integrity and long-term cell survival. Emerging knowledge indicates that calcium homeostasis is not only critical for cell physiology and health, but also, when deregulated, can lead to neurodegeneration via complex and diverse mechanisms involved in selective neuronal impairments and death. The identification of several modulators of calcium homeostasis, such as presenilins and CALHM1, as potential factors involved in the pathogenesis of Alzheimer's disease, provides strong support for a role of calcium in neurodegeneration. These observations represent an important step towards understanding the molecular mechanisms of calcium signaling disturbances observed in different brain diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.</p> |
| first_indexed | 2024-04-13T02:53:56Z |
| format | Article |
| id | doaj.art-5929e669e952404dbdf4677cbb04d976 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-04-13T02:53:56Z |
| publishDate | 2009-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-5929e669e952404dbdf4677cbb04d9762022-12-22T03:05:45ZengBMCMolecular Neurodegeneration1750-13262009-05-01412010.1186/1750-1326-4-20Calcium signaling in neurodegenerationDreses-Werringloer UteMarambaud PhilippeVingtdeux Valérie<p>Abstract</p> <p>Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular level of the versatility of this ion has made overwhelming progress in the past several years and has been extensively reviewed. In the brain, calcium is fundamental in the control of synaptic activity and memory formation, a process that leads to the activation of specific calcium-dependent signal transduction pathways and implicates key protein effectors, such as CaMKs, MAPK/ERKs, and CREB. Properly controlled homeostasis of calcium signaling not only supports normal brain physiology but also maintains neuronal integrity and long-term cell survival. Emerging knowledge indicates that calcium homeostasis is not only critical for cell physiology and health, but also, when deregulated, can lead to neurodegeneration via complex and diverse mechanisms involved in selective neuronal impairments and death. The identification of several modulators of calcium homeostasis, such as presenilins and CALHM1, as potential factors involved in the pathogenesis of Alzheimer's disease, provides strong support for a role of calcium in neurodegeneration. These observations represent an important step towards understanding the molecular mechanisms of calcium signaling disturbances observed in different brain diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.</p>http://www.molecularneurodegeneration.com/content/4/1/20 |
| spellingShingle | Dreses-Werringloer Ute Marambaud Philippe Vingtdeux Valérie Calcium signaling in neurodegeneration Molecular Neurodegeneration |
| title | Calcium signaling in neurodegeneration |
| title_full | Calcium signaling in neurodegeneration |
| title_fullStr | Calcium signaling in neurodegeneration |
| title_full_unstemmed | Calcium signaling in neurodegeneration |
| title_short | Calcium signaling in neurodegeneration |
| title_sort | calcium signaling in neurodegeneration |
| url | http://www.molecularneurodegeneration.com/content/4/1/20 |
| work_keys_str_mv | AT dreseswerringloerute calciumsignalinginneurodegeneration AT marambaudphilippe calciumsignalinginneurodegeneration AT vingtdeuxvalerie calciumsignalinginneurodegeneration |