Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate
Objective: To compare blunting of hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients. Study Design: Prospective comparative study. Place and Duration of Study: Anaesthesia Department Combined Military Hospital, Lahore Pakistan, from Ja...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2022-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/5374 |
| _version_ | 1828048792391254016 |
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| author | Rehana Feroze Aftab Hussain Mehwish Naseer |
| author_facet | Rehana Feroze Aftab Hussain Mehwish Naseer |
| author_sort | Rehana Feroze |
| collection | DOAJ |
| description |
Objective: To compare blunting of hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients.
Study Design: Prospective comparative study.
Place and Duration of Study: Anaesthesia Department Combined Military Hospital, Lahore Pakistan, from Jan to Jun 2019.
Methodology: A total of 232 hypertensive patients of the ASA status II, undergoing elective surgical procedures requiring intubation, were randomly divided into two groups, Group-L (Lidocaine) and Group-M (Magnesium Sulphate). Lidocaine 1.5mg/kg was given to Group-L 90 seconds before laryngoscopy, whereas Magnesium Sulphate 30mg/kg was given over ten minutes to Group-M before laryngoscopy. Baseline means arterial pressure was recorded. Mean arterial pressure was subsequently recorded each minute after intubation for five minutes.
Results: Both groups were similar with regard to demographic data. After intubation, both groups had an increase in mean arterial pressures. Blunting of stress response was observed in 78 patients (67.2%) in Group-L and 55 patients (47.4%) in Group-M. Two groups showed a significant statistical difference (p=0.003).
Conclusion: Both drugs are effective in blunting hemodynamic stress response to intubation in hypertensive patients, but Lidocaine is more effective than Magnesium Sulphate.
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| first_indexed | 2024-04-10T19:02:15Z |
| format | Article |
| id | doaj.art-592a242e52634cf9bdfb1fffdf82b0e6 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-10T19:02:15Z |
| publishDate | 2022-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-592a242e52634cf9bdfb1fffdf82b0e62023-01-31T08:20:29ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-12-0172610.51253/pafmj.v72i6.5374Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium SulphateRehana Feroze0Aftab Hussain1Mehwish Naseer2Combined Military Hospital, Lahore Medical College/National University of Medical Science (NUMS)PakistanCombined Military Hospital, Lahore/National University of Medical Science (NUMS)PakistanArmy Cardiac Centre Lahore Pakistan Objective: To compare blunting of hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients. Study Design: Prospective comparative study. Place and Duration of Study: Anaesthesia Department Combined Military Hospital, Lahore Pakistan, from Jan to Jun 2019. Methodology: A total of 232 hypertensive patients of the ASA status II, undergoing elective surgical procedures requiring intubation, were randomly divided into two groups, Group-L (Lidocaine) and Group-M (Magnesium Sulphate). Lidocaine 1.5mg/kg was given to Group-L 90 seconds before laryngoscopy, whereas Magnesium Sulphate 30mg/kg was given over ten minutes to Group-M before laryngoscopy. Baseline means arterial pressure was recorded. Mean arterial pressure was subsequently recorded each minute after intubation for five minutes. Results: Both groups were similar with regard to demographic data. After intubation, both groups had an increase in mean arterial pressures. Blunting of stress response was observed in 78 patients (67.2%) in Group-L and 55 patients (47.4%) in Group-M. Two groups showed a significant statistical difference (p=0.003). Conclusion: Both drugs are effective in blunting hemodynamic stress response to intubation in hypertensive patients, but Lidocaine is more effective than Magnesium Sulphate. https://pafmj.org/index.php/PAFMJ/article/view/5374Hemodynamic stabilityHypertensive patientsLidocaineMagnesium SulphateStress responseTracheal intubation |
| spellingShingle | Rehana Feroze Aftab Hussain Mehwish Naseer Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate Pakistan Armed Forces Medical Journal Hemodynamic stability Hypertensive patients Lidocaine Magnesium Sulphate Stress response Tracheal intubation |
| title | Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate |
| title_full | Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate |
| title_fullStr | Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate |
| title_full_unstemmed | Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate |
| title_short | Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate |
| title_sort | blunting stress response during intubation in hypertensive patients a comparison between lidocaine and magnesium sulphate |
| topic | Hemodynamic stability Hypertensive patients Lidocaine Magnesium Sulphate Stress response Tracheal intubation |
| url | https://pafmj.org/index.php/PAFMJ/article/view/5374 |
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