SWI/SNF complex, promising target in melanoma therapy: Snapshot view
Therapeutic strategies based on epigenetic regulators are rapidly increasing in light of recent advances in discovering the role of epigenetic factors in response and sensitivity to therapy. Although loss-of-function mutations in genes encoding the SWItch/Sucrose NonFermentable (SWI/SNF) subunits pl...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1096615/full |
| _version_ | 1811168339252215808 |
|---|---|
| author | Mahsa Mollapour Sisakht Mahsa Mollapour Sisakht Mohammad Amir Amirkhani Mohammad Ali Nilforoushzadeh |
| author_facet | Mahsa Mollapour Sisakht Mahsa Mollapour Sisakht Mohammad Amir Amirkhani Mohammad Ali Nilforoushzadeh |
| author_sort | Mahsa Mollapour Sisakht |
| collection | DOAJ |
| description | Therapeutic strategies based on epigenetic regulators are rapidly increasing in light of recent advances in discovering the role of epigenetic factors in response and sensitivity to therapy. Although loss-of-function mutations in genes encoding the SWItch/Sucrose NonFermentable (SWI/SNF) subunits play an important role in the occurrence of ~34% of melanomas, the potential of using inhibitors and synthetic lethality interactions between key subunits of the complex that play an important role in melanoma progression must be considered. Here, we discuss the importance of the clinical application of SWI/SNF subunits as a promising potential therapeutic in melanoma. |
| first_indexed | 2024-04-10T16:25:44Z |
| format | Article |
| id | doaj.art-592a88d870924431bcd5f888f031804c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T16:25:44Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-592a88d870924431bcd5f888f031804c2023-02-09T06:29:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-011010.3389/fmed.2023.10966151096615SWI/SNF complex, promising target in melanoma therapy: Snapshot viewMahsa Mollapour Sisakht0Mahsa Mollapour Sisakht1Mohammad Amir Amirkhani2Mohammad Ali Nilforoushzadeh3Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Biochemistry, Erasmus University Medical Center, Rotterdam, NetherlandsSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IranSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IranTherapeutic strategies based on epigenetic regulators are rapidly increasing in light of recent advances in discovering the role of epigenetic factors in response and sensitivity to therapy. Although loss-of-function mutations in genes encoding the SWItch/Sucrose NonFermentable (SWI/SNF) subunits play an important role in the occurrence of ~34% of melanomas, the potential of using inhibitors and synthetic lethality interactions between key subunits of the complex that play an important role in melanoma progression must be considered. Here, we discuss the importance of the clinical application of SWI/SNF subunits as a promising potential therapeutic in melanoma.https://www.frontiersin.org/articles/10.3389/fmed.2023.1096615/fullmelanomaSWI/SNF enzymesepigeneticschromatin remodelingsynthetic lethalitycancer therapy |
| spellingShingle | Mahsa Mollapour Sisakht Mahsa Mollapour Sisakht Mohammad Amir Amirkhani Mohammad Ali Nilforoushzadeh SWI/SNF complex, promising target in melanoma therapy: Snapshot view Frontiers in Medicine melanoma SWI/SNF enzymes epigenetics chromatin remodeling synthetic lethality cancer therapy |
| title | SWI/SNF complex, promising target in melanoma therapy: Snapshot view |
| title_full | SWI/SNF complex, promising target in melanoma therapy: Snapshot view |
| title_fullStr | SWI/SNF complex, promising target in melanoma therapy: Snapshot view |
| title_full_unstemmed | SWI/SNF complex, promising target in melanoma therapy: Snapshot view |
| title_short | SWI/SNF complex, promising target in melanoma therapy: Snapshot view |
| title_sort | swi snf complex promising target in melanoma therapy snapshot view |
| topic | melanoma SWI/SNF enzymes epigenetics chromatin remodeling synthetic lethality cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1096615/full |
| work_keys_str_mv | AT mahsamollapoursisakht swisnfcomplexpromisingtargetinmelanomatherapysnapshotview AT mahsamollapoursisakht swisnfcomplexpromisingtargetinmelanomatherapysnapshotview AT mohammadamiramirkhani swisnfcomplexpromisingtargetinmelanomatherapysnapshotview AT mohammadalinilforoushzadeh swisnfcomplexpromisingtargetinmelanomatherapysnapshotview |