Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats
We developed a new estimation system using rapid prototyping technology that focuses on the relationship between the architecture and mechanical properties of trabecular bone. The system uses three-dimensional acrylic resin models of trabecular bone constructed from micro-CT data to predict the mech...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2007-10-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/2/4/2_4_178/_pdf/-char/en |
| _version_ | 1811296805256691712 |
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| author | Takatoshi UMENO Toshiaki HARA Naoto ENDO |
| author_facet | Takatoshi UMENO Toshiaki HARA Naoto ENDO |
| author_sort | Takatoshi UMENO |
| collection | DOAJ |
| description | We developed a new estimation system using rapid prototyping technology that focuses on the relationship between the architecture and mechanical properties of trabecular bone. The system uses three-dimensional acrylic resin models of trabecular bone constructed from micro-CT data to predict the mechanical properties of trabecular bone. We used this method to clarify the relationship between loading orientation and bone fragility in the vertebral trabecular bone of ovariectomized (OVX) rats. Twenty 6-week-old female Wistar rats were randomly divided into two groups (OVX and normal groups). Five rats from each group were killed at 3 and 6 weeks following operations and the L4 vertebra was removed. Bone specimens from both groups were scanned using a micro-CT system. Subsequently, resin models of the bone were fabricated at 60× magnification from the micro-CT data sets using laser stereolithography. The resin models were subjected to compressive testing in three orthogonal orientations corresponding to the craniocaudal, mediolateral, and anteroposterior anatomic axes. The results showed that the elastic modulus and ultimate stress were lower in the models of OVX rats than in the normal rats, the mechanical properties of trabecular bone structure from OVX rats deteriorated with increasing time postoperatively, and the elastic moduli in the mediolateral and anteroposterior axes were especially reduced relative to the decrease in the craniocaudal axis in the OVX rats. |
| first_indexed | 2024-04-13T05:54:01Z |
| format | Article |
| id | doaj.art-592a911b284844a9bb883af11f8cce89 |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-13T05:54:01Z |
| publishDate | 2007-10-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-592a911b284844a9bb883af11f8cce892022-12-22T02:59:40ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632007-10-012417818610.1299/jbse.2.178jbseFragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) RatsTakatoshi UMENO0Toshiaki HARA1Naoto ENDO2Faculty of Education, Fukuoka University of EducationFaculty of Engineering, Niigata UniversityFaculty of Medicine, Niigata UniversityWe developed a new estimation system using rapid prototyping technology that focuses on the relationship between the architecture and mechanical properties of trabecular bone. The system uses three-dimensional acrylic resin models of trabecular bone constructed from micro-CT data to predict the mechanical properties of trabecular bone. We used this method to clarify the relationship between loading orientation and bone fragility in the vertebral trabecular bone of ovariectomized (OVX) rats. Twenty 6-week-old female Wistar rats were randomly divided into two groups (OVX and normal groups). Five rats from each group were killed at 3 and 6 weeks following operations and the L4 vertebra was removed. Bone specimens from both groups were scanned using a micro-CT system. Subsequently, resin models of the bone were fabricated at 60× magnification from the micro-CT data sets using laser stereolithography. The resin models were subjected to compressive testing in three orthogonal orientations corresponding to the craniocaudal, mediolateral, and anteroposterior anatomic axes. The results showed that the elastic modulus and ultimate stress were lower in the models of OVX rats than in the normal rats, the mechanical properties of trabecular bone structure from OVX rats deteriorated with increasing time postoperatively, and the elastic moduli in the mediolateral and anteroposterior axes were especially reduced relative to the decrease in the craniocaudal axis in the OVX rats.https://www.jstage.jst.go.jp/article/jbse/2/4/2_4_178/_pdf/-char/enboneosteoporosisratmechanical propertyrapid prototyping technology |
| spellingShingle | Takatoshi UMENO Toshiaki HARA Naoto ENDO Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats Journal of Biomechanical Science and Engineering bone osteoporosis rat mechanical property rapid prototyping technology |
| title | Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats |
| title_full | Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats |
| title_fullStr | Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats |
| title_full_unstemmed | Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats |
| title_short | Fragility of Vertebral Trabecular Bone under Various Loading Orientations in Ovariectomized (OVX) Rats |
| title_sort | fragility of vertebral trabecular bone under various loading orientations in ovariectomized ovx rats |
| topic | bone osteoporosis rat mechanical property rapid prototyping technology |
| url | https://www.jstage.jst.go.jp/article/jbse/2/4/2_4_178/_pdf/-char/en |
| work_keys_str_mv | AT takatoshiumeno fragilityofvertebraltrabecularboneundervariousloadingorientationsinovariectomizedovxrats AT toshiakihara fragilityofvertebraltrabecularboneundervariousloadingorientationsinovariectomizedovxrats AT naotoendo fragilityofvertebraltrabecularboneundervariousloadingorientationsinovariectomizedovxrats |