sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates
Background: Small for gestational age is a pregnancy complication associated with a variety of adverse perinatal outcomes. The aim of the study was to investigate if sFlt-1/PlGF ratio is related to adverse short-term neonatal outcome in neonates small for gestational age in normotensive pregnancy. M...
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MDPI AG
2021-08-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/8/718 |
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| author | Jacek Witwicki Katarzyna Chaberek Natalia Szymecka-Samaha Adam Krysiak Paweł Pietruski Katarzyna Kosińska-Kaczyńska |
| author_facet | Jacek Witwicki Katarzyna Chaberek Natalia Szymecka-Samaha Adam Krysiak Paweł Pietruski Katarzyna Kosińska-Kaczyńska |
| author_sort | Jacek Witwicki |
| collection | DOAJ |
| description | Background: Small for gestational age is a pregnancy complication associated with a variety of adverse perinatal outcomes. The aim of the study was to investigate if sFlt-1/PlGF ratio is related to adverse short-term neonatal outcome in neonates small for gestational age in normotensive pregnancy. Methods: A prospective observational study was conducted. Serum sFlt-1/PlGF ratio was measured in women in singleton gestation diagnosed with fetus small for gestational age. Short-term neonatal outcome analyzed in the period between birth and discharge home. Results: Eighty-two women were included. Women with sFlt-1/PlGF ratio ≥33 gave birth to neonates with lower birthweight at lower gestational age. Neonates from high ratio group suffered from respiratory disorders and NEC significantly more often. They were hospitalized at NICU more often and were discharged home significantly later. sFlt-1/PlGF ratio predicted combined neonatal outcome with sensitivity of 73% and specificity of 82.2%. Conclusions: sFlt-1/PlGF ratio is a useful toll in prediction of short-term adverse neonatal outcome in SGA pregnancies. |
| first_indexed | 2024-03-10T08:54:30Z |
| format | Article |
| id | doaj.art-592ac2ed045a44e7879ae4fb2952ebae |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T08:54:30Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-592ac2ed045a44e7879ae4fb2952ebae2023-11-22T07:14:54ZengMDPI AGChildren2227-90672021-08-018871810.3390/children8080718sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age NeonatesJacek Witwicki0Katarzyna Chaberek1Natalia Szymecka-Samaha2Adam Krysiak3Paweł Pietruski4Katarzyna Kosińska-Kaczyńska5Department of Neonatology, Centre of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, Poland2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, Poland2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, PolandDepartment of Neonatology, Centre of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, PolandIndependent Public Complex of Healthcare Institutions in Pułtusk, 3 Maja 5, 06-100 Pułtusk, Poland2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, PolandBackground: Small for gestational age is a pregnancy complication associated with a variety of adverse perinatal outcomes. The aim of the study was to investigate if sFlt-1/PlGF ratio is related to adverse short-term neonatal outcome in neonates small for gestational age in normotensive pregnancy. Methods: A prospective observational study was conducted. Serum sFlt-1/PlGF ratio was measured in women in singleton gestation diagnosed with fetus small for gestational age. Short-term neonatal outcome analyzed in the period between birth and discharge home. Results: Eighty-two women were included. Women with sFlt-1/PlGF ratio ≥33 gave birth to neonates with lower birthweight at lower gestational age. Neonates from high ratio group suffered from respiratory disorders and NEC significantly more often. They were hospitalized at NICU more often and were discharged home significantly later. sFlt-1/PlGF ratio predicted combined neonatal outcome with sensitivity of 73% and specificity of 82.2%. Conclusions: sFlt-1/PlGF ratio is a useful toll in prediction of short-term adverse neonatal outcome in SGA pregnancies.https://www.mdpi.com/2227-9067/8/8/718fetal growth restrictionsmall for gestational ageneonatal outcomepredictionPlGFsFlt-1 |
| spellingShingle | Jacek Witwicki Katarzyna Chaberek Natalia Szymecka-Samaha Adam Krysiak Paweł Pietruski Katarzyna Kosińska-Kaczyńska sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates Children fetal growth restriction small for gestational age neonatal outcome prediction PlGF sFlt-1 |
| title | sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates |
| title_full | sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates |
| title_fullStr | sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates |
| title_full_unstemmed | sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates |
| title_short | sFlt-1/PlGF Ratio in Prediction of Short-Term Neonatal Outcome of Small for Gestational Age Neonates |
| title_sort | sflt 1 plgf ratio in prediction of short term neonatal outcome of small for gestational age neonates |
| topic | fetal growth restriction small for gestational age neonatal outcome prediction PlGF sFlt-1 |
| url | https://www.mdpi.com/2227-9067/8/8/718 |
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