Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents

Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents

Objective: Hepatic steatosis is a key initiating event in the pathogenesis of alcohol-associated liver disease (ALD), the most detrimental organ damage resulting from alcohol use disorder. However, the mechanisms by which alcohol induces steatosis remain incompletely understood. We have previously f...

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Bibliographic Details
Main Authors: Chunxue Zhou, Henry H. Ruiz, Li Ling, Giulia Maurizi, Kenichi Sakamoto, Claudia G. Liberini, Ling Wang, Adrien Stanley, Hale E. Egritag, Sofia M. Sanz, Claudia Lindtner, Mary A. Butera, Christoph Buettner
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Metabolism
Subjects:
Sympathetic outflow
Adipose triglyceride lipase
Tyrosine hydroxylase
β3 adrenergic agonism
Insulin signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001473

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