Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity
Abstract Background Genetic factors have been suggested to affect the efficacy of working memory training. However, few studies have attempted to identify the relevant genes. Methods In this study, we first performed a randomized controlled trial (RCT) to identify brain regions that were specificall...
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1523 |
| _version_ | 1818204922684899328 |
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| author | Wan Zhao Ling Huang Yang Li Qiumei Zhang Xiongying Chen Wenjin Fu Boqi Du Xiaoxiang Deng Feng Ji Yu‐Tao Xiang Chuanyue Wang Xiaohong Li Qi Dong Chuansheng Chen Susanne M. Jaeggi Jun Li |
| author_facet | Wan Zhao Ling Huang Yang Li Qiumei Zhang Xiongying Chen Wenjin Fu Boqi Du Xiaoxiang Deng Feng Ji Yu‐Tao Xiang Chuanyue Wang Xiaohong Li Qi Dong Chuansheng Chen Susanne M. Jaeggi Jun Li |
| author_sort | Wan Zhao |
| collection | DOAJ |
| description | Abstract Background Genetic factors have been suggested to affect the efficacy of working memory training. However, few studies have attempted to identify the relevant genes. Methods In this study, we first performed a randomized controlled trial (RCT) to identify brain regions that were specifically affected by working memory training. Sixty undergraduate students were randomly assigned to either the adaptive training group (N = 30) or the active control group (N = 30). Both groups were trained for 20 sessions during 4 weeks and received fMRI scans before and after the training. Afterward, we combined the data from the 30 participants in the RCT study who received adaptive training with data from 71 additional participants who also received the same adaptive training but were not part of the RCT study (total N = 101) to test the contribution of the COMT Val158/108Met polymorphism to the interindividual difference in the training effect within the identified brain regions. Results In the RCT study, we found that the adaptive training significantly decreased brain activation in the left prefrontal cortex (TFCE‐FWE corrected p = .030). In the genetic study, we found that compared with the Val allele homozygotes, the Met allele carriers' brain activation decreased more after the training at the left prefrontal cortex (TFCE‐FWE corrected p = .025). Conclusions This study provided evidence for the neural effect of a visual–spatial span training and suggested that genetic factors such as the COMT Val158/108Met polymorphism may have to be considered in future studies of such training. |
| first_indexed | 2024-12-12T03:48:56Z |
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| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-12T03:48:56Z |
| publishDate | 2020-02-01 |
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| series | Brain and Behavior |
| spelling | doaj.art-592fc8a71c924d7495f9f277b54324702022-12-22T00:39:27ZengWileyBrain and Behavior2162-32792020-02-01102n/an/a10.1002/brb3.1523Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticityWan Zhao0Ling Huang1Yang Li2Qiumei Zhang3Xiongying Chen4Wenjin Fu5Boqi Du6Xiaoxiang Deng7Feng Ji8Yu‐Tao Xiang9Chuanyue Wang10Xiaohong Li11Qi Dong12Chuansheng Chen13Susanne M. Jaeggi14Jun Li15State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia Beijing Anding Hospital Capital Medical University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaSchool of Mental Health Jining Medical University Jining ChinaFaculty of Health Sciences University of Macau Taipa ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia Beijing Anding Hospital Capital Medical University Beijing ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia Beijing Anding Hospital Capital Medical University Beijing ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaDepartment of Psychological Science University of California Irvine CA USASchool of Education & Department of Cognitive Sciences University of California Irvine CA USAState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research Beijing Normal University Beijing ChinaAbstract Background Genetic factors have been suggested to affect the efficacy of working memory training. However, few studies have attempted to identify the relevant genes. Methods In this study, we first performed a randomized controlled trial (RCT) to identify brain regions that were specifically affected by working memory training. Sixty undergraduate students were randomly assigned to either the adaptive training group (N = 30) or the active control group (N = 30). Both groups were trained for 20 sessions during 4 weeks and received fMRI scans before and after the training. Afterward, we combined the data from the 30 participants in the RCT study who received adaptive training with data from 71 additional participants who also received the same adaptive training but were not part of the RCT study (total N = 101) to test the contribution of the COMT Val158/108Met polymorphism to the interindividual difference in the training effect within the identified brain regions. Results In the RCT study, we found that the adaptive training significantly decreased brain activation in the left prefrontal cortex (TFCE‐FWE corrected p = .030). In the genetic study, we found that compared with the Val allele homozygotes, the Met allele carriers' brain activation decreased more after the training at the left prefrontal cortex (TFCE‐FWE corrected p = .025). Conclusions This study provided evidence for the neural effect of a visual–spatial span training and suggested that genetic factors such as the COMT Val158/108Met polymorphism may have to be considered in future studies of such training.https://doi.org/10.1002/brb3.1523COMTfMRIgene polymorphismrandomized controlled trialworking memory training |
| spellingShingle | Wan Zhao Ling Huang Yang Li Qiumei Zhang Xiongying Chen Wenjin Fu Boqi Du Xiaoxiang Deng Feng Ji Yu‐Tao Xiang Chuanyue Wang Xiaohong Li Qi Dong Chuansheng Chen Susanne M. Jaeggi Jun Li Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity Brain and Behavior COMT fMRI gene polymorphism randomized controlled trial working memory training |
| title | Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity |
| title_full | Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity |
| title_fullStr | Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity |
| title_full_unstemmed | Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity |
| title_short | Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training‐related prefrontal plasticity |
| title_sort | evidence for the contribution of comt gene val158 108met polymorphism rs4680 to working memory training related prefrontal plasticity |
| topic | COMT fMRI gene polymorphism randomized controlled trial working memory training |
| url | https://doi.org/10.1002/brb3.1523 |
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