Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment
Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists. Genetic markers provide promising avenues for investiga...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423003262 |
| _version_ | 1797390546536235008 |
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| author | Wirawan Adikusuma Firdayani Firdayani Lalu Muhammad Irham Darmawi Darmawi Muhammad Yulis Hamidy Baiq Leny Nopitasari Soraya Soraya Nurul Azizah |
| author_facet | Wirawan Adikusuma Firdayani Firdayani Lalu Muhammad Irham Darmawi Darmawi Muhammad Yulis Hamidy Baiq Leny Nopitasari Soraya Soraya Nurul Azizah |
| author_sort | Wirawan Adikusuma |
| collection | DOAJ |
| description | Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists. Genetic markers provide promising avenues for investigating the treatment of hemorrhoids, as they may reveal intricate biological mechanisms and targeted drug therapies, ultimately enhancing more precise treatment tailored to the patient. This study aims to identify new drug candidates for treating hemorrhoids through a meticulous bioinformatics approach and integrated with genomic network analysis. After extracting 21 druggable target genes using DrugBank from 293 genes connected to hemorrhoids, 87 possible drugs were selected. Three of these drugs (ketamine, methylene blue, and fulvestrant) hold potential in addressing issues associated with hemorrhoids and have been supported by clinical or preclinical studies. Eighty-four compounds present new therapeutic possibilities for managing hemorrhoids. We highlight that our findings indicate that NOX1 and NOS3 genes are promising biomarkers, with NOS3 gaining significance owing to its robust systemic functional annotations. Sapropterin, an existing drug, is closely associated with NOS3, providing a clear target for biomarker-driven interventions. This study illustrates the potential of combining genomic network analysis with bioinformatics to repurpose drugs for treating hemorrhoids. Subsequent research will explore the mechanisms for utilizing NOS3 targeting in the treatment of hemorrhoids. |
| first_indexed | 2024-03-08T23:13:23Z |
| format | Article |
| id | doaj.art-5932a7e71c6341c7918470e919f24f6d |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-08T23:13:23Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-5932a7e71c6341c7918470e919f24f6d2023-12-15T07:22:53ZengElsevierSaudi Pharmaceutical Journal1319-01642023-12-013112101831Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatmentWirawan Adikusuma0Firdayani Firdayani1Lalu Muhammad Irham2Darmawi Darmawi3Muhammad Yulis Hamidy4Baiq Leny Nopitasari5Soraya Soraya6Nurul Azizah7Departement of Pharmacy, University of Muhammadiyah Mataram, Mataram, Indonesia; Research Center for Vaccine and Drugs, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia; Corresponding author at: Departement of Pharmacy, University of Muhammadiyah Mataram, Mataram, Indonesia.Research Center for Vaccine and Drugs, National Research and Innovation Agency (BRIN), South Tangerang, IndonesiaFaculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaDepartment of Histology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia; Graduate School in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, IndonesiaDepartment of Pharmacology, Faculty of Medicine, Universitas Riau, Pekanbaru, IndonesiaDepartement of Pharmacy, University of Muhammadiyah Mataram, Mataram, IndonesiaMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, IndonesiaMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, IndonesiaHemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists. Genetic markers provide promising avenues for investigating the treatment of hemorrhoids, as they may reveal intricate biological mechanisms and targeted drug therapies, ultimately enhancing more precise treatment tailored to the patient. This study aims to identify new drug candidates for treating hemorrhoids through a meticulous bioinformatics approach and integrated with genomic network analysis. After extracting 21 druggable target genes using DrugBank from 293 genes connected to hemorrhoids, 87 possible drugs were selected. Three of these drugs (ketamine, methylene blue, and fulvestrant) hold potential in addressing issues associated with hemorrhoids and have been supported by clinical or preclinical studies. Eighty-four compounds present new therapeutic possibilities for managing hemorrhoids. We highlight that our findings indicate that NOX1 and NOS3 genes are promising biomarkers, with NOS3 gaining significance owing to its robust systemic functional annotations. Sapropterin, an existing drug, is closely associated with NOS3, providing a clear target for biomarker-driven interventions. This study illustrates the potential of combining genomic network analysis with bioinformatics to repurpose drugs for treating hemorrhoids. Subsequent research will explore the mechanisms for utilizing NOS3 targeting in the treatment of hemorrhoids.http://www.sciencedirect.com/science/article/pii/S1319016423003262Drug repositioningGenomic network analysisHemorrhoidsSapropterin |
| spellingShingle | Wirawan Adikusuma Firdayani Firdayani Lalu Muhammad Irham Darmawi Darmawi Muhammad Yulis Hamidy Baiq Leny Nopitasari Soraya Soraya Nurul Azizah Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment Saudi Pharmaceutical Journal Drug repositioning Genomic network analysis Hemorrhoids Sapropterin |
| title | Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| title_full | Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| title_fullStr | Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| title_full_unstemmed | Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| title_short | Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| title_sort | integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment |
| topic | Drug repositioning Genomic network analysis Hemorrhoids Sapropterin |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423003262 |
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