Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma
Background: Meningioma is a common intracranial tumor arising from the meningothelial (arachnoid) cells. Meningiomas are divided into 15 histological subtypes and three grades, including benign (grade I), atypical (grade II) and anaplastic (grade III). It is important to correctly decide whether a m...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2021-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_112010.html |
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| author | Samar U. Hasan* Rasha M. Abdelkareem Ahmed A. S. A. ELhakeem Ali R. Hamdan Eman M. S. Muhammad |
| author_facet | Samar U. Hasan* Rasha M. Abdelkareem Ahmed A. S. A. ELhakeem Ali R. Hamdan Eman M. S. Muhammad |
| author_sort | Samar U. Hasan* |
| collection | DOAJ |
| description | Background: Meningioma is a common intracranial tumor arising from the meningothelial (arachnoid) cells. Meningiomas are divided into 15 histological subtypes and three grades, including benign (grade I), atypical (grade II) and anaplastic (grade III). It is important to correctly decide whether a meningioma isbrain-invasive or not. Tumor invasion can be described as a stepwise process involving the degradation of the extracellular matrix (ECM), tumor cell adhesion to resident cells or components, increased proliferation, and cell migration into new intracellular/ECM space. It is believed that expression of Matrix metalloproteinases (MMPs) can be related with this process, especially the matrix metalloproteinase-9 (MMP9). Objectives: Investigation of matrix metalloproteinase-9 expression in different grades of meningioma and correlate this expression with brain invasion. Patients and methods: Matrix metalloproteinase-9 immunostaining was studied in 50 specimens of meningioma using avidin-biotin peroxidase method. Results: The percentage of brain invasive was 5% as regard to MMP9 score 1 ,5% as regard MMP9 score 2,20% as regard MMP9 score 3,70% as regard MMP9 score 4. A significant positive correlation was found between MMP9score and brain invasion (p < 0.001). Conclusion: Increased MMP9 expression is correlated with brain invasion. |
| first_indexed | 2024-12-18T02:46:12Z |
| format | Article |
| id | doaj.art-5932fdf36cee4bb8b69495fde1afc95d |
| institution | Directory Open Access Journal |
| issn | 2636-3402 2735-427X |
| language | English |
| last_indexed | 2024-12-18T02:46:12Z |
| publishDate | 2021-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-5932fdf36cee4bb8b69495fde1afc95d2022-12-21T21:23:33ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2636-34022735-427X2021-07-01412225https://dx.doi.org/10.21608/svuijm.2021.112010 Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningiomaSamar U. Hasan*0 Rasha M. Abdelkareem1 Ahmed A. S. A. ELhakeem2Ali R. Hamdan3 Eman M. S. Muhammad4Pathology Department,Faculty of Medicine, SouthValleyUniversity,Qena,EgyptPathology Department, Faculty of Medicine, Sohag University, Sohag, EgyptPathology Department, Faculty of Medicine, AL-Azhar University, Asuit, Egypt.Neurosurgery Department, Faculty of Medicine, South Valley University, Qena, EgyptPathology Department, Faculty of Medicine, Sohag University, Sohag, EgyptBackground: Meningioma is a common intracranial tumor arising from the meningothelial (arachnoid) cells. Meningiomas are divided into 15 histological subtypes and three grades, including benign (grade I), atypical (grade II) and anaplastic (grade III). It is important to correctly decide whether a meningioma isbrain-invasive or not. Tumor invasion can be described as a stepwise process involving the degradation of the extracellular matrix (ECM), tumor cell adhesion to resident cells or components, increased proliferation, and cell migration into new intracellular/ECM space. It is believed that expression of Matrix metalloproteinases (MMPs) can be related with this process, especially the matrix metalloproteinase-9 (MMP9). Objectives: Investigation of matrix metalloproteinase-9 expression in different grades of meningioma and correlate this expression with brain invasion. Patients and methods: Matrix metalloproteinase-9 immunostaining was studied in 50 specimens of meningioma using avidin-biotin peroxidase method. Results: The percentage of brain invasive was 5% as regard to MMP9 score 1 ,5% as regard MMP9 score 2,20% as regard MMP9 score 3,70% as regard MMP9 score 4. A significant positive correlation was found between MMP9score and brain invasion (p < 0.001). Conclusion: Increased MMP9 expression is correlated with brain invasion.https://svuijm.journals.ekb.eg/article_112010.htmlmatrix metalloproteinase-9; meningioma; invasion |
| spellingShingle | Samar U. Hasan* Rasha M. Abdelkareem Ahmed A. S. A. ELhakeem Ali R. Hamdan Eman M. S. Muhammad Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma SVU - International Journal of Medical Sciences matrix metalloproteinase-9; meningioma; invasion |
| title | Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma |
| title_full | Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma |
| title_fullStr | Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma |
| title_full_unstemmed | Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma |
| title_short | Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma |
| title_sort | immunohistochemical expression of matrix metalloproteinase 9 in invasive meningioma |
| topic | matrix metalloproteinase-9; meningioma; invasion |
| url | https://svuijm.journals.ekb.eg/article_112010.html |
| work_keys_str_mv | AT samaruhasan immunohistochemicalexpressionofmatrixmetalloproteinase9ininvasivemeningioma AT rashamabdelkareem immunohistochemicalexpressionofmatrixmetalloproteinase9ininvasivemeningioma AT ahmedasaelhakeem immunohistochemicalexpressionofmatrixmetalloproteinase9ininvasivemeningioma AT alirhamdan immunohistochemicalexpressionofmatrixmetalloproteinase9ininvasivemeningioma AT emanmsmuhammad immunohistochemicalexpressionofmatrixmetalloproteinase9ininvasivemeningioma |