Therapeutic applications of transdermal microneedles
Transdermal drug-delivery systems (TDDS) offer an attractive alternative to the oral route for delivery of biotherapeutics. Technological advancements in the past few decades have revolutionized the fabrication of micro-structured devices including creation of microneedles (MC). These devices are us...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-10-01
|
| Series: | Frontiers in Bioscience-Elite |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBE/13/1/10.2741/876 |
| _version_ | 1818027578278019072 |
|---|---|
| author | Sumeet Kumar Singla Arunachalam Muthuraman Diksha Sahai Naveen Mangal Jagadeesh Dhamodharan |
| author_facet | Sumeet Kumar Singla Arunachalam Muthuraman Diksha Sahai Naveen Mangal Jagadeesh Dhamodharan |
| author_sort | Sumeet Kumar Singla |
| collection | DOAJ |
| description | Transdermal drug-delivery systems (TDDS) offer an attractive alternative to the oral route for delivery of biotherapeutics. Technological advancements in the past few decades have revolutionized the fabrication of micro-structured devices including creation of microneedles (MC). These devices are used for delivering peptides, macromolecules such as proteins and DNA, and other therapeutics through the skin. Here, we review the current use of MCs as a cost effective method for the self-administration of therapeutics. We will then review the current and common use of MCs as an effective treatment strategy for a broad range of diseases and their utility in the generation of effective vaccination delivery platforms. Finally, we will summarize the currently FDA approved MCs and their applications, along with the ongoing clinical trials that use such devices. |
| first_indexed | 2024-12-10T04:50:07Z |
| format | Article |
| id | doaj.art-5933bd97e75d4616bcc61757eed03c42 |
| institution | Directory Open Access Journal |
| issn | 1945-0494 |
| language | English |
| last_indexed | 2024-12-10T04:50:07Z |
| publishDate | 2020-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Elite |
| spelling | doaj.art-5933bd97e75d4616bcc61757eed03c422022-12-22T02:01:38ZengIMR PressFrontiers in Bioscience-Elite1945-04942020-10-0113115818410.2741/876S1945-0494(21)00007-2Therapeutic applications of transdermal microneedlesSumeet Kumar Singla0Arunachalam Muthuraman1Diksha Sahai2Naveen Mangal3Jagadeesh Dhamodharan4College of Pharmacy, University of Iowa, Iowa City, IA, 52246Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaCollege of Professional Studies, Northeastern University, Boston, MA, USA – 02115Independent Clinical Pharmacologist, Billerica, MA 01821, USADepartment of Anatomy, Faculty of Medicine, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaTransdermal drug-delivery systems (TDDS) offer an attractive alternative to the oral route for delivery of biotherapeutics. Technological advancements in the past few decades have revolutionized the fabrication of micro-structured devices including creation of microneedles (MC). These devices are used for delivering peptides, macromolecules such as proteins and DNA, and other therapeutics through the skin. Here, we review the current use of MCs as a cost effective method for the self-administration of therapeutics. We will then review the current and common use of MCs as an effective treatment strategy for a broad range of diseases and their utility in the generation of effective vaccination delivery platforms. Finally, we will summarize the currently FDA approved MCs and their applications, along with the ongoing clinical trials that use such devices.https://www.imrpress.com/journal/FBE/13/1/10.2741/876alzheimer diseasediabetes mellitusimmunityobesitytransdermal drug deliveryvaccine therapyreview |
| spellingShingle | Sumeet Kumar Singla Arunachalam Muthuraman Diksha Sahai Naveen Mangal Jagadeesh Dhamodharan Therapeutic applications of transdermal microneedles Frontiers in Bioscience-Elite alzheimer disease diabetes mellitus immunity obesity transdermal drug delivery vaccine therapy review |
| title | Therapeutic applications of transdermal microneedles |
| title_full | Therapeutic applications of transdermal microneedles |
| title_fullStr | Therapeutic applications of transdermal microneedles |
| title_full_unstemmed | Therapeutic applications of transdermal microneedles |
| title_short | Therapeutic applications of transdermal microneedles |
| title_sort | therapeutic applications of transdermal microneedles |
| topic | alzheimer disease diabetes mellitus immunity obesity transdermal drug delivery vaccine therapy review |
| url | https://www.imrpress.com/journal/FBE/13/1/10.2741/876 |
| work_keys_str_mv | AT sumeetkumarsingla therapeuticapplicationsoftransdermalmicroneedles AT arunachalammuthuraman therapeuticapplicationsoftransdermalmicroneedles AT dikshasahai therapeuticapplicationsoftransdermalmicroneedles AT naveenmangal therapeuticapplicationsoftransdermalmicroneedles AT jagadeeshdhamodharan therapeuticapplicationsoftransdermalmicroneedles |