Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles
Step emulsification, which uses a geometry-dependent mechanism for generating uniformly sized droplets, has recently gained considerable attention because of its robustness against flow fluctuations. However, like shear-based droplet generation, step emulsification is susceptible to impurities cause...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/14/3/622 |
| _version_ | 1797610062248673280 |
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| author | Guangchong Ji Yusuke Kanno Takasi Nisisako |
| author_facet | Guangchong Ji Yusuke Kanno Takasi Nisisako |
| author_sort | Guangchong Ji |
| collection | DOAJ |
| description | Step emulsification, which uses a geometry-dependent mechanism for generating uniformly sized droplets, has recently gained considerable attention because of its robustness against flow fluctuations. However, like shear-based droplet generation, step emulsification is susceptible to impurities caused by satellite droplets. Herein, we demonstrate the integration of deterministic lateral displacement (DLD) to separate the main and satellite droplets produced during step emulsification. Step-emulsification nozzles (16 μm deep) in the upstream region of the proposed device were arrayed on the sidewalls of the main channel (91 μm deep). In the downstream region, the DLD micropillars were arrayed periodically with a critical diameter (cut-off value for size-based separation) of 37 μm. When an acrylate monomer and aqueous polyvinyl alcohol solution were infused as the dispersed and continuous phases, respectively, the nozzles produced monodisperse main droplets in the dripping regime, with an average diameter of ~60 μm, coefficient of variation (CV) value below 3%, and satellite droplets of ~3 μm. Upon entering the DLD region near the sidewall, these main and satellite droplets were gradually separated through the pillars based on their sizes. Finally, off-chip photopolymerization yielded monodisperse polymeric microspheres with an average diameter of 55 μm and a CV value of 2.9% (<i>n</i> = 202). |
| first_indexed | 2024-03-11T06:09:15Z |
| format | Article |
| id | doaj.art-59346ec1c1cb4dee97bd6c950a8f356e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-11T06:09:15Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-59346ec1c1cb4dee97bd6c950a8f356e2023-11-17T12:43:23ZengMDPI AGMicromachines2072-666X2023-03-0114362210.3390/mi14030622Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and ParticlesGuangchong Ji0Yusuke Kanno1Takasi Nisisako2Department of Mechanical Engineering, School of Engineering, Tokyo Institute of Technology, Tokyo 152-8550, JapanInstitute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, JapanInstitute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, JapanStep emulsification, which uses a geometry-dependent mechanism for generating uniformly sized droplets, has recently gained considerable attention because of its robustness against flow fluctuations. However, like shear-based droplet generation, step emulsification is susceptible to impurities caused by satellite droplets. Herein, we demonstrate the integration of deterministic lateral displacement (DLD) to separate the main and satellite droplets produced during step emulsification. Step-emulsification nozzles (16 μm deep) in the upstream region of the proposed device were arrayed on the sidewalls of the main channel (91 μm deep). In the downstream region, the DLD micropillars were arrayed periodically with a critical diameter (cut-off value for size-based separation) of 37 μm. When an acrylate monomer and aqueous polyvinyl alcohol solution were infused as the dispersed and continuous phases, respectively, the nozzles produced monodisperse main droplets in the dripping regime, with an average diameter of ~60 μm, coefficient of variation (CV) value below 3%, and satellite droplets of ~3 μm. Upon entering the DLD region near the sidewall, these main and satellite droplets were gradually separated through the pillars based on their sizes. Finally, off-chip photopolymerization yielded monodisperse polymeric microspheres with an average diameter of 55 μm and a CV value of 2.9% (<i>n</i> = 202).https://www.mdpi.com/2072-666X/14/3/622step emulsificationdeterministic lateral displacementdroplet separationsatellite dropletspolymeric microspheres |
| spellingShingle | Guangchong Ji Yusuke Kanno Takasi Nisisako Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles Micromachines step emulsification deterministic lateral displacement droplet separation satellite droplets polymeric microspheres |
| title | Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles |
| title_full | Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles |
| title_fullStr | Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles |
| title_full_unstemmed | Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles |
| title_short | Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles |
| title_sort | microfluidic coupling of step emulsification and deterministic lateral displacement for producing satellite free droplets and particles |
| topic | step emulsification deterministic lateral displacement droplet separation satellite droplets polymeric microspheres |
| url | https://www.mdpi.com/2072-666X/14/3/622 |
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