REGULATORY T CELLS IN CHILDREN WITH ALLERGY
Abstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represen...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/120 |
| _version_ | 1797198157361184768 |
|---|---|
| author | A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin |
| author_facet | A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin |
| author_sort | A. Donetskova |
| collection | DOAJ |
| description | Abstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represent some mechanisms of their therapeutic effects. The amount of Treg’s gradually decrease with age in non-atopic children; they also decrease in atopic ones until 6 years, followed by their subsequent stabilization. Thus, a hypothesis is proposed, that the initial changes of Treg’s in case of allergy comprise a reduction in their functions, and, upon complete or partial compensation of this defect by increasing of cell amounts, a remission is initiated. However, in absence of compensation, acute attacks of allergic disorders are developed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 159-166). |
| first_indexed | 2024-03-08T05:51:33Z |
| format | Article |
| id | doaj.art-593497381ab94796868d1ae2861b365b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:24Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-593497381ab94796868d1ae2861b365b2024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-315916610.15789/1563-0625-2008-2-3-159-166117REGULATORY T CELLS IN CHILDREN WITH ALLERGYA. Donetskova0N. Sharova1M. Litvina2O. Burmenskaya3D. Trofimov4M. Yartsev5L. Alexeev6A. Yarilin7ГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваГНЦ – Институт иммунологии ФМБА России, МоскваAbstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represent some mechanisms of their therapeutic effects. The amount of Treg’s gradually decrease with age in non-atopic children; they also decrease in atopic ones until 6 years, followed by their subsequent stabilization. Thus, a hypothesis is proposed, that the initial changes of Treg’s in case of allergy comprise a reduction in their functions, and, upon complete or partial compensation of this defect by increasing of cell amounts, a remission is initiated. However, in absence of compensation, acute attacks of allergic disorders are developed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 159-166).https://www.mimmun.ru/mimmun/article/view/120regulatory t-cellscd4+cd25hifoxp3allergychildren |
| spellingShingle | A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin REGULATORY T CELLS IN CHILDREN WITH ALLERGY Медицинская иммунология regulatory t-cells cd4+cd25hi foxp3 allergy children |
| title | REGULATORY T CELLS IN CHILDREN WITH ALLERGY |
| title_full | REGULATORY T CELLS IN CHILDREN WITH ALLERGY |
| title_fullStr | REGULATORY T CELLS IN CHILDREN WITH ALLERGY |
| title_full_unstemmed | REGULATORY T CELLS IN CHILDREN WITH ALLERGY |
| title_short | REGULATORY T CELLS IN CHILDREN WITH ALLERGY |
| title_sort | regulatory t cells in children with allergy |
| topic | regulatory t-cells cd4+cd25hi foxp3 allergy children |
| url | https://www.mimmun.ru/mimmun/article/view/120 |
| work_keys_str_mv | AT adonetskova regulatorytcellsinchildrenwithallergy AT nsharova regulatorytcellsinchildrenwithallergy AT mlitvina regulatorytcellsinchildrenwithallergy AT oburmenskaya regulatorytcellsinchildrenwithallergy AT dtrofimov regulatorytcellsinchildrenwithallergy AT myartsev regulatorytcellsinchildrenwithallergy AT lalexeev regulatorytcellsinchildrenwithallergy AT ayarilin regulatorytcellsinchildrenwithallergy |