Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.
Bibliographic Details
| Main Authors: |
Takaaki Akaike,
Tomoaki Ida,
Fan-Yan Wei,
Motohiro Nishida,
Yoshito Kumagai,
Md. Morshedul Alam,
Hideshi Ihara,
Tomohiro Sawa,
Tetsuro Matsunaga,
Shingo Kasamatsu,
Akiyuki Nishimura,
Masanobu Morita,
Kazuhito Tomizawa,
Akira Nishimura,
Satoshi Watanabe,
Kenji Inaba,
Hiroshi Shima,
Nobuhiro Tanuma,
Minkyung Jung,
Shigemoto Fujii,
Yasuo Watanabe,
Masaki Ohmuraya,
Péter Nagy,
Martin Feelisch,
Jon M. Fukuto,
Hozumi Motohashi |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2017-10-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-017-01311-y
|
|---|