Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01311-y |
| _version_ | 1818856311444471808 |
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| author | Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi |
| author_facet | Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi |
| author_sort | Takaaki Akaike |
| collection | DOAJ |
| description | Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation. |
| first_indexed | 2024-12-19T08:22:29Z |
| format | Article |
| id | doaj.art-59355d393d744dc18b1812f57d180eae |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:22:29Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-59355d393d744dc18b1812f57d180eae2022-12-21T20:29:22ZengNature PortfolioNature Communications2041-17232017-10-018111510.1038/s41467-017-01311-yCysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergeticsTakaaki Akaike0Tomoaki Ida1Fan-Yan Wei2Motohiro Nishida3Yoshito Kumagai4Md. Morshedul Alam5Hideshi Ihara6Tomohiro Sawa7Tetsuro Matsunaga8Shingo Kasamatsu9Akiyuki Nishimura10Masanobu Morita11Kazuhito Tomizawa12Akira Nishimura13Satoshi Watanabe14Kenji Inaba15Hiroshi Shima16Nobuhiro Tanuma17Minkyung Jung18Shigemoto Fujii19Yasuo Watanabe20Masaki Ohmuraya21Péter Nagy22Martin Feelisch23Jon M. Fukuto24Hozumi Motohashi25Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDepartment of Molecular Physiology, Graduate School of Medical Sciences, Kumamoto UniversityDivision of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural SciencesEnvironmental Biology Section, Faculty of Medicine, University of TsukubaDepartment of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Biological Science, Graduate School of Science, Osaka Prefecture UniversityDepartment of Microbiology, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDivision of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural SciencesDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDepartment of Molecular Physiology, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityDivision of Cancer Chemotherapy, Miyagi Cancer Center Research InstituteDivision of Cancer Chemotherapy, Miyagi Cancer Center Research InstituteDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of MedicineLaboratory of Pharmacology, Showa Pharmaceutical UniversityDepartment of Genetics, Hyogo College of Medicine, NishinomiyaDepartment of Molecular Immunology and Toxicology, National Institute of OncologyClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital and Institute for Life SciencesDepartment of Chemistry, Sonoma State UniversityDepartment of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku UniversityCysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.https://doi.org/10.1038/s41467-017-01311-y |
| spellingShingle | Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics Nature Communications |
| title | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_full | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_fullStr | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_full_unstemmed | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_short | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_sort | cysteinyl trna synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| url | https://doi.org/10.1038/s41467-017-01311-y |
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