Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2349 |
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| author | Amarjitsing Rajput Riyaz Ali M. Osmani Achyut Khire Sanket Jaiswal Rinti Banerjee |
| author_facet | Amarjitsing Rajput Riyaz Ali M. Osmani Achyut Khire Sanket Jaiswal Rinti Banerjee |
| author_sort | Amarjitsing Rajput |
| collection | DOAJ |
| description | Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (−23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days. Conclusion: The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch. |
| first_indexed | 2024-03-09T11:35:50Z |
| format | Article |
| id | doaj.art-5937a9f69f334b5a84642e5952212dc1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:35:50Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5937a9f69f334b5a84642e5952212dc12023-11-30T23:43:02ZengMDPI AGMolecules1420-30492022-04-01277234910.3390/molecules27072349Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo CharacterizationAmarjitsing Rajput0Riyaz Ali M. Osmani1Achyut Khire2Sanket Jaiswal3Rinti Banerjee4Nanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, IndiaNanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, IndiaNanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, IndiaNanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, IndiaNanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, IndiaBackground: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (−23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days. Conclusion: The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch.https://www.mdpi.com/1420-3049/27/7/2349drug deliverynanotechnologycontraceptionlevonorgestrelliposomesmicroneedle |
| spellingShingle | Amarjitsing Rajput Riyaz Ali M. Osmani Achyut Khire Sanket Jaiswal Rinti Banerjee Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization Molecules drug delivery nanotechnology contraception levonorgestrel liposomes microneedle |
| title | Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization |
| title_full | Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization |
| title_fullStr | Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization |
| title_full_unstemmed | Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization |
| title_short | Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization |
| title_sort | levonorgestrel microneedle array patch for sustained release contraception formulation optimization and in vivo characterization |
| topic | drug delivery nanotechnology contraception levonorgestrel liposomes microneedle |
| url | https://www.mdpi.com/1420-3049/27/7/2349 |
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