Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation

<p>Abstract</p> <p>Background</p> <p>As myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation. However, the impact of induced blood flow...

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Bibliographic Details
Main Authors: Wang Jiun, Dharmakumar Rohan, Green Jordin D, Flewitt Jacqueline A, Vöhringer Matthias, Tyberg John V, Friedrich Matthias G
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Journal of Cardiovascular Magnetic Resonance
Online Access:http://www.jcmr-online.com/content/12/1/20
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Summary:<p>Abstract</p> <p>Background</p> <p>As myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation. However, the impact of induced blood flow changes on oxygenation is not well understood. We used oxygenation-sensitive CMR to assess the relations between myocardial oxygenation and coronary sinus blood oxygen saturation (SvO<sub>2</sub>) and coronary blood flow in a dog model in which hyperemia was induced by intracoronary administration of vasodilators.</p> <p>Results</p> <p>During administration of acetylcholine and adenosine, CMR signal intensity correlated linearly with simultaneously measured SvO<sub>2 </sub>(<it>r</it><sup>2 </sup>= 0.74, <it>P </it>< 0.001). Both SvO<sub>2 </sub>and CMR signal intensity were exponentially related to coronary blood flow, with SvO2 approaching 87%.</p> <p>Conclusions</p> <p>Myocardial oxygenation as assessed with oxygenation-sensitive CMR imaging is linearly related to SvO<sub>2 </sub>and is exponentially related to vasodilator-induced increases of blood flow. Oxygenation-sensitive CMR may be useful to assess ischemia and microvascular function in patients. Its clinical utility should be evaluated.</p>
ISSN:1097-6647
1532-429X