Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro

Summary: Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and OC-affiliated transcription factors (TFs) during ost...

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Bibliographic Details
Main Authors: Valentina S. Caputo, Nikolaos Trasanidis, Xiaolin Xiao, Mark E. Robinson, Alexia Katsarou, Kanagaraju Ponnusamy, Rab K. Prinjha, Nicholas Smithers, Aristeidis Chaidos, Holger W. Auner, Anastasios Karadimitris
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Biological Sciences
Developmental Biology
Bioinformatics
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422031186X

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