Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study
AbstractPurpose To compare the efficacy of ultrasound-guided percutaneous microwave ablation (MWA) without subsequent lumpectomy and breast-conserving surgery (BCS) in patients with early breast cancer (BC).Materials and methods This retrospective cohort study enrolled 106 patients with early BC (T0...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2186325 |
| _version_ | 1827397126918766592 |
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| author | Yu-qing Dai Ping Liang Jiandong Wang Yan-chun Luo Xiao-Ling Yu Zhi-Yu Han Fang-yi Liu Xin Li Shui-lian Tan Zhen Wang Chong Wu Jian-ming Li Jie Yu |
| author_facet | Yu-qing Dai Ping Liang Jiandong Wang Yan-chun Luo Xiao-Ling Yu Zhi-Yu Han Fang-yi Liu Xin Li Shui-lian Tan Zhen Wang Chong Wu Jian-ming Li Jie Yu |
| author_sort | Yu-qing Dai |
| collection | DOAJ |
| description | AbstractPurpose To compare the efficacy of ultrasound-guided percutaneous microwave ablation (MWA) without subsequent lumpectomy and breast-conserving surgery (BCS) in patients with early breast cancer (BC).Materials and methods This retrospective cohort study enrolled 106 patients with early BC (T0/1/2 N0/1 M0) treated by MWA (n = 21) or BCS (n = 85) from October 2014 to December 2020. Propensity score matching (PSM) was performed to balance the baseline characteristics between MWA and BCS groups. The tumor progression, overall survival (OS), disease-specific survival (DSS), complications, and cosmetic results were compared.Results After PSM, there were 21 patients with balanced baseline characteristics in each group. After a median follow-up of 43 months (range, 15–89 months), there was no significant difference in tumor progression (10% vs 2%, p = 0.18), OS (96% vs 99%, p = 0.36), DSS (100% vs 99%, p > 0.99), and complications (0% vs 19%, p = 0.58). The operation time of MWA was shorter (60 min vs 101 min, p < 0.001) than that of BCS. For the management of metastatic lymph nodes, five (5/21, 24%) patients with six metastatic nodes underwent ablation in the MWA group and three patients (3/21, 14%) with six metastatic nodes underwent axillary lymph node dissection in the BCS group. All the patients in the MWA group reported excellent cosmetic results, but 29% of BCS patients expressed dissatisfaction with breast asymmetry (10%) and scar formation (19%) (p < 0.001).Conclusion This pilot study indicated that in selected early BC patients, microwave ablation without subsequent lumpectomy had comparable tumor control effect with breast-conserving surgery and better cosmetic results at an intermediate follow-up.HighlightsMWA without subsequent lumpectomy has a comparable interim survival effect and better cosmetic results as BCS in the treatment of selected early breast cancer.MWA has the potential to be a viable and promising therapeutic option for breast cancer patients reluctant or intolerant to surgery with the advantage of minimal invasion. |
| first_indexed | 2024-03-08T19:02:44Z |
| format | Article |
| id | doaj.art-593ad12dd6df490391ebcd7e0cd12ce5 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:44Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-593ad12dd6df490391ebcd7e0cd12ce52023-12-28T04:15:42ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2186325Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching studyYu-qing Dai0Ping Liang1Jiandong Wang2Yan-chun Luo3Xiao-Ling Yu4Zhi-Yu Han5Fang-yi Liu6Xin Li7Shui-lian Tan8Zhen Wang9Chong Wu10Jian-ming Li11Jie Yu12Department of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Breast Surgery, Chinese PLA Medical College, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaAbstractPurpose To compare the efficacy of ultrasound-guided percutaneous microwave ablation (MWA) without subsequent lumpectomy and breast-conserving surgery (BCS) in patients with early breast cancer (BC).Materials and methods This retrospective cohort study enrolled 106 patients with early BC (T0/1/2 N0/1 M0) treated by MWA (n = 21) or BCS (n = 85) from October 2014 to December 2020. Propensity score matching (PSM) was performed to balance the baseline characteristics between MWA and BCS groups. The tumor progression, overall survival (OS), disease-specific survival (DSS), complications, and cosmetic results were compared.Results After PSM, there were 21 patients with balanced baseline characteristics in each group. After a median follow-up of 43 months (range, 15–89 months), there was no significant difference in tumor progression (10% vs 2%, p = 0.18), OS (96% vs 99%, p = 0.36), DSS (100% vs 99%, p > 0.99), and complications (0% vs 19%, p = 0.58). The operation time of MWA was shorter (60 min vs 101 min, p < 0.001) than that of BCS. For the management of metastatic lymph nodes, five (5/21, 24%) patients with six metastatic nodes underwent ablation in the MWA group and three patients (3/21, 14%) with six metastatic nodes underwent axillary lymph node dissection in the BCS group. All the patients in the MWA group reported excellent cosmetic results, but 29% of BCS patients expressed dissatisfaction with breast asymmetry (10%) and scar formation (19%) (p < 0.001).Conclusion This pilot study indicated that in selected early BC patients, microwave ablation without subsequent lumpectomy had comparable tumor control effect with breast-conserving surgery and better cosmetic results at an intermediate follow-up.HighlightsMWA without subsequent lumpectomy has a comparable interim survival effect and better cosmetic results as BCS in the treatment of selected early breast cancer.MWA has the potential to be a viable and promising therapeutic option for breast cancer patients reluctant or intolerant to surgery with the advantage of minimal invasion.https://www.tandfonline.com/doi/10.1080/02656736.2023.2186325Microwavesretrospective studiespropensity scorebreast neoplasmsultrasonographyinterventional |
| spellingShingle | Yu-qing Dai Ping Liang Jiandong Wang Yan-chun Luo Xiao-Ling Yu Zhi-Yu Han Fang-yi Liu Xin Li Shui-lian Tan Zhen Wang Chong Wu Jian-ming Li Jie Yu Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study International Journal of Hyperthermia Microwaves retrospective studies propensity score breast neoplasms ultrasonography interventional |
| title | Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study |
| title_full | Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study |
| title_fullStr | Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study |
| title_full_unstemmed | Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study |
| title_short | Microwave ablation without subsequent lumpectomy versus breast-conserving surgery for early breast cancer: a propensity score matching study |
| title_sort | microwave ablation without subsequent lumpectomy versus breast conserving surgery for early breast cancer a propensity score matching study |
| topic | Microwaves retrospective studies propensity score breast neoplasms ultrasonography interventional |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2186325 |
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