Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes

Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes

(1) Background: Around 50% of hemophilia patients develop severe arthropathy, with even subclinical hemorrhage in childhood potentially leading to intra-articular iron deposition, synovia proliferation, neoangiogenesis, and eventual damage to articular cartilage and subchondral bone. Treatments typi...

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Bibliographic Details
Main Authors: Nele Wagener, Sebastian Hardt, Matthias Pumberger, Friederike Schömig
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Journal of Clinical Medicine
Subjects:
hemophilic arthropathy
ferroptosis
cartilage destruction
bone defects
hemophilia
hemarthrosis
Online Access:https://www.mdpi.com/2077-0383/13/2/559

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