In vitro characterization of a nineteenth-century therapy for smallpox.
In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections. The work described characterizes the antipoxvirus act...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3302891?pdf=render |
| _version_ | 1818953141930950656 |
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| author | William Arndt Chandra Mitnik Karen L Denzler Stacy White Robert Waters Bertram L Jacobs Yvan Rochon Victoria A Olson Inger K Damon Jeffrey O Langland |
| author_facet | William Arndt Chandra Mitnik Karen L Denzler Stacy White Robert Waters Bertram L Jacobs Yvan Rochon Victoria A Olson Inger K Damon Jeffrey O Langland |
| author_sort | William Arndt |
| collection | DOAJ |
| description | In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections. The work described characterizes the antipoxvirus activity associated with this botanical extract against vaccinia virus, monkeypox virus and variola virus, the causative agent of smallpox. Our work demonstrates the in vitro characterization of Sarracenia purpurea as the first effective inhibitor of poxvirus replication at the level of early viral transcription. With the renewed threat of poxvirus-related infections, our results indicate Sarracenia purpurea may act as another defensive measure against Orthopoxvirus infections. |
| first_indexed | 2024-12-20T10:01:34Z |
| format | Article |
| id | doaj.art-593adf58d9ea417ba9b2f4985eddd56d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T10:01:34Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-593adf58d9ea417ba9b2f4985eddd56d2022-12-21T19:44:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3261010.1371/journal.pone.0032610In vitro characterization of a nineteenth-century therapy for smallpox.William ArndtChandra MitnikKaren L DenzlerStacy WhiteRobert WatersBertram L JacobsYvan RochonVictoria A OlsonInger K DamonJeffrey O LanglandIn the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections. The work described characterizes the antipoxvirus activity associated with this botanical extract against vaccinia virus, monkeypox virus and variola virus, the causative agent of smallpox. Our work demonstrates the in vitro characterization of Sarracenia purpurea as the first effective inhibitor of poxvirus replication at the level of early viral transcription. With the renewed threat of poxvirus-related infections, our results indicate Sarracenia purpurea may act as another defensive measure against Orthopoxvirus infections.http://europepmc.org/articles/PMC3302891?pdf=render |
| spellingShingle | William Arndt Chandra Mitnik Karen L Denzler Stacy White Robert Waters Bertram L Jacobs Yvan Rochon Victoria A Olson Inger K Damon Jeffrey O Langland In vitro characterization of a nineteenth-century therapy for smallpox. PLoS ONE |
| title | In vitro characterization of a nineteenth-century therapy for smallpox. |
| title_full | In vitro characterization of a nineteenth-century therapy for smallpox. |
| title_fullStr | In vitro characterization of a nineteenth-century therapy for smallpox. |
| title_full_unstemmed | In vitro characterization of a nineteenth-century therapy for smallpox. |
| title_short | In vitro characterization of a nineteenth-century therapy for smallpox. |
| title_sort | in vitro characterization of a nineteenth century therapy for smallpox |
| url | http://europepmc.org/articles/PMC3302891?pdf=render |
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