Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients
Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-02-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1810495 |
| _version_ | 1797677278825545728 |
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| author | Angela Bechini Paolo Bonanni Maddalena Grazzini Diana Paolini Giulio Arcangeli Nicola Mucci Costanza Bini Emilia Tiscione Beatrice Zanella Sara Boccalini |
| author_facet | Angela Bechini Paolo Bonanni Maddalena Grazzini Diana Paolini Giulio Arcangeli Nicola Mucci Costanza Bini Emilia Tiscione Beatrice Zanella Sara Boccalini |
| author_sort | Angela Bechini |
| collection | DOAJ |
| description | Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases. |
| first_indexed | 2024-03-11T22:41:47Z |
| format | Article |
| id | doaj.art-593c17aaa01c4055b814894331ffe44f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:47Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-593c17aaa01c4055b814894331ffe44f2023-09-22T08:51:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-02-0117258058210.1080/21645515.2020.18104951810495Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patientsAngela Bechini0Paolo Bonanni1Maddalena Grazzini2Diana Paolini3Giulio Arcangeli4Nicola Mucci5Costanza Bini6Emilia Tiscione7Beatrice Zanella8Sara Boccalini9University of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceUniversity of FlorenceBoth our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases.http://dx.doi.org/10.1080/21645515.2020.1810495hepatitis bvaccinationhealthcare workerschronic patientsnon-respondersadditional dosesanti-hbs testing |
| spellingShingle | Angela Bechini Paolo Bonanni Maddalena Grazzini Diana Paolini Giulio Arcangeli Nicola Mucci Costanza Bini Emilia Tiscione Beatrice Zanella Sara Boccalini Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients Human Vaccines & Immunotherapeutics hepatitis b vaccination healthcare workers chronic patients non-responders additional doses anti-hbs testing |
| title | Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients |
| title_full | Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients |
| title_fullStr | Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients |
| title_full_unstemmed | Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients |
| title_short | Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients |
| title_sort | need to take special care of non responders to hepatitis b vaccination among health care workers students and chronic patients |
| topic | hepatitis b vaccination healthcare workers chronic patients non-responders additional doses anti-hbs testing |
| url | http://dx.doi.org/10.1080/21645515.2020.1810495 |
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