Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review
BackgroundCholangiocarcinoma (CCA) is a type of malignant tumor that arises from the epithelium of the bile ducts. According to anatomical location, CCA can be classified as intrahepatic (ICC), perihilar (PCC), or extrahepatic (ECC). CCA can invade and metastasize to other tissues in various ways, b...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.922834/full |
| _version_ | 1798042845230137344 |
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| author | Hongwei Qian Hongwei Qian Zhikun Huang Zhikun Huang Xuezheng Sun Xuezheng Sun Peitu Ren Peitu Ren |
| author_facet | Hongwei Qian Hongwei Qian Zhikun Huang Zhikun Huang Xuezheng Sun Xuezheng Sun Peitu Ren Peitu Ren |
| author_sort | Hongwei Qian |
| collection | DOAJ |
| description | BackgroundCholangiocarcinoma (CCA) is a type of malignant tumor that arises from the epithelium of the bile ducts. According to anatomical location, CCA can be classified as intrahepatic (ICC), perihilar (PCC), or extrahepatic (ECC). CCA can invade and metastasize to other tissues in various ways, but distal skeletal muscle metastasis (SMM) is extremely rare. There are several reports on SMM from ICC or PCC, but SMM from ECC has not yet been reported.Case presentationA 71-year-old woman was diagnosed with ECC, for which she underwent pancreatoduodenectomy and partial hepatectomy. Nine months after surgery, she was re-admitted to the hospital complaining of a rapidly growing mass on her right thigh with progressive lower extremity edema. Magnetic resonance imaging of the right thigh showed two masses with iso-signal intensity on T1-weighted images and hyper-intensity on T2-weighted images compared with the surrounding muscles. Pathological examination of the fine-needle biopsy specimen revealed that it was similar to the previously detected ECC, and the diagnosis was metastasis of ECC. The patient was treated with opioid analgesics and died of systemic failure three months later.ConclusionSMM should be considered during the follow-up period despite its low incidence, and perineural invasion may be an essential pathway of distant metastasis in CCA. |
| first_indexed | 2024-04-11T22:41:23Z |
| format | Article |
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| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T22:41:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-593c60829163418eb234458b508c9d8d2022-12-22T03:58:59ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-08-01910.3389/fsurg.2022.922834922834Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature reviewHongwei Qian0Hongwei Qian1Zhikun Huang2Zhikun Huang3Xuezheng Sun4Xuezheng Sun5Peitu Ren6Peitu Ren7Department of Hepatobiliary and Pancreatic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, ChinaShaoxing Key Laboratory of Minimally Invasive Abdominal Surgery and Precise Treatment of Tumor, Shaoxing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, ChinaShaoxing Key Laboratory of Minimally Invasive Abdominal Surgery and Precise Treatment of Tumor, Shaoxing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, ChinaShaoxing Key Laboratory of Minimally Invasive Abdominal Surgery and Precise Treatment of Tumor, Shaoxing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, ChinaShaoxing Key Laboratory of Minimally Invasive Abdominal Surgery and Precise Treatment of Tumor, Shaoxing, ChinaBackgroundCholangiocarcinoma (CCA) is a type of malignant tumor that arises from the epithelium of the bile ducts. According to anatomical location, CCA can be classified as intrahepatic (ICC), perihilar (PCC), or extrahepatic (ECC). CCA can invade and metastasize to other tissues in various ways, but distal skeletal muscle metastasis (SMM) is extremely rare. There are several reports on SMM from ICC or PCC, but SMM from ECC has not yet been reported.Case presentationA 71-year-old woman was diagnosed with ECC, for which she underwent pancreatoduodenectomy and partial hepatectomy. Nine months after surgery, she was re-admitted to the hospital complaining of a rapidly growing mass on her right thigh with progressive lower extremity edema. Magnetic resonance imaging of the right thigh showed two masses with iso-signal intensity on T1-weighted images and hyper-intensity on T2-weighted images compared with the surrounding muscles. Pathological examination of the fine-needle biopsy specimen revealed that it was similar to the previously detected ECC, and the diagnosis was metastasis of ECC. The patient was treated with opioid analgesics and died of systemic failure three months later.ConclusionSMM should be considered during the follow-up period despite its low incidence, and perineural invasion may be an essential pathway of distant metastasis in CCA.https://www.frontiersin.org/articles/10.3389/fsurg.2022.922834/fullcholangiocarcinomaskeletal muscle metastasispathologicalperineural invasioncase report |
| spellingShingle | Hongwei Qian Hongwei Qian Zhikun Huang Zhikun Huang Xuezheng Sun Xuezheng Sun Peitu Ren Peitu Ren Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review Frontiers in Surgery cholangiocarcinoma skeletal muscle metastasis pathological perineural invasion case report |
| title | Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review |
| title_full | Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review |
| title_fullStr | Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review |
| title_full_unstemmed | Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review |
| title_short | Skeletal muscle metastasis from extrahepatic cholangiocarcinoma: A case report and literature review |
| title_sort | skeletal muscle metastasis from extrahepatic cholangiocarcinoma a case report and literature review |
| topic | cholangiocarcinoma skeletal muscle metastasis pathological perineural invasion case report |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.922834/full |
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