NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation

NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation

Abstract Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the dose‐limiting toxicity of combined treatmen...

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Bibliographic Details
Main Authors: Lorena Giuranno, Eloy M. Roig, Carolien Wansleeben, Annette van denBerg, Arjan J. Groot, Ludwig Dubois, Marc Vooijs
Format: Article
Language:English
Published: Oxford University Press 2020-07-01
Series:Stem Cells Translational Medicine
Subjects:
air‐liquid interface system
NOTCH signaling
primary bronchial epithelial cells
radiation‐induced lung injury
radiotherapy
Online Access:https://doi.org/10.1002/sctm.19-0278

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