The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.
Stunting, anemia and inflammation are frequently observed in children with end-stage renal disease (ESRD).To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis (HD) and peritoneal dialysis (PD).54...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4596869?pdf=render |
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| author | Juliana Casimiro de Almeida Randall Lou-Meda Marion Olbert Markus Seifert Günter Weiss Erwin T Wiegerinck Dorine W Swinkels Noel W Solomons Klaus Schümann |
| author_facet | Juliana Casimiro de Almeida Randall Lou-Meda Marion Olbert Markus Seifert Günter Weiss Erwin T Wiegerinck Dorine W Swinkels Noel W Solomons Klaus Schümann |
| author_sort | Juliana Casimiro de Almeida |
| collection | DOAJ |
| description | Stunting, anemia and inflammation are frequently observed in children with end-stage renal disease (ESRD).To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis (HD) and peritoneal dialysis (PD).54 juveniles 7-20 years of age were recruited in FUNDANIER, Guatemala City: 27 on HD and 27 PD. Hemoglobin, serum iron, transferrin, serum transferrin receptor (sTfR), serum ferritin, transferrin saturation and iron-binding capacity, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), as well as IL-6, IL-1 and TNF-α, weight and height were determined by standard methods. Hepcidin-25 (Hep-25) was assessed by weak cation exchange time-of-flight mass-spectrometry.92% and 55% of HD and PD children, respectively, were stunted and 95% and 85% were anemic. Among iron status biomarkers, serum ferritin was massively increased and significantly higher in the HD group compared to the PD group. Hep-25 was also greatly elevated in both groups. 41% of HD patients showed increments in three or more inflammatory biomarkers, while it was 2 or less in all PD subjects.The degree of stunting, the prevalence and severity of anemia in Guatemalan juvenile ESRD far exceed the national statistics for this low-income Central American country. Ferritin and Hep-25 concentrations were elevated, with the latter to an extraordinary magnitude. Additional biomarkers of inflammation not directly related to iron status were elevated as well. The role of both disease- and environment-related factors in combination best explains the magnitude of the biomarker abnormalities. |
| first_indexed | 2024-12-11T01:42:18Z |
| format | Article |
| id | doaj.art-5941aa04cac94c1ea6c013eae3e75acb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T01:42:18Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5941aa04cac94c1ea6c013eae3e75acb2022-12-22T01:25:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014006210.1371/journal.pone.0140062The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.Juliana Casimiro de AlmeidaRandall Lou-MedaMarion OlbertMarkus SeifertGünter WeissErwin T WiegerinckDorine W SwinkelsNoel W SolomonsKlaus SchümannStunting, anemia and inflammation are frequently observed in children with end-stage renal disease (ESRD).To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis (HD) and peritoneal dialysis (PD).54 juveniles 7-20 years of age were recruited in FUNDANIER, Guatemala City: 27 on HD and 27 PD. Hemoglobin, serum iron, transferrin, serum transferrin receptor (sTfR), serum ferritin, transferrin saturation and iron-binding capacity, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), as well as IL-6, IL-1 and TNF-α, weight and height were determined by standard methods. Hepcidin-25 (Hep-25) was assessed by weak cation exchange time-of-flight mass-spectrometry.92% and 55% of HD and PD children, respectively, were stunted and 95% and 85% were anemic. Among iron status biomarkers, serum ferritin was massively increased and significantly higher in the HD group compared to the PD group. Hep-25 was also greatly elevated in both groups. 41% of HD patients showed increments in three or more inflammatory biomarkers, while it was 2 or less in all PD subjects.The degree of stunting, the prevalence and severity of anemia in Guatemalan juvenile ESRD far exceed the national statistics for this low-income Central American country. Ferritin and Hep-25 concentrations were elevated, with the latter to an extraordinary magnitude. Additional biomarkers of inflammation not directly related to iron status were elevated as well. The role of both disease- and environment-related factors in combination best explains the magnitude of the biomarker abnormalities.http://europepmc.org/articles/PMC4596869?pdf=render |
| spellingShingle | Juliana Casimiro de Almeida Randall Lou-Meda Marion Olbert Markus Seifert Günter Weiss Erwin T Wiegerinck Dorine W Swinkels Noel W Solomons Klaus Schümann The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. PLoS ONE |
| title | The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. |
| title_full | The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. |
| title_fullStr | The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. |
| title_full_unstemmed | The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. |
| title_short | The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. |
| title_sort | growth attainment hematological iron status and inflammatory profile of guatemalan juvenile end stage renal disease patients |
| url | http://europepmc.org/articles/PMC4596869?pdf=render |
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