In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine
Introduction: Visual manifestations are the most prominent non-painful features of migraine. During the last decades, visual area V3a has gathered attention of headache scientists because of its apparent implication on aura initiation, photophobia and cortical hyper-responsiveness related to visual...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-10-01
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| Series: | Cephalalgia Reports |
| Online Access: | https://doi.org/10.1177/2515816320964405 |
| _version_ | 1818882100025098240 |
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| author | Marco Lisicki Mariela Carpinella Gianluca Coppola Tatiana Castro Zamparella Emiliano Ruiz-Romagnoli Maïté Manise Alain Maertens de Noordhout Jean Schoenen Diego Conci Magris |
| author_facet | Marco Lisicki Mariela Carpinella Gianluca Coppola Tatiana Castro Zamparella Emiliano Ruiz-Romagnoli Maïté Manise Alain Maertens de Noordhout Jean Schoenen Diego Conci Magris |
| author_sort | Marco Lisicki |
| collection | DOAJ |
| description | Introduction: Visual manifestations are the most prominent non-painful features of migraine. During the last decades, visual area V3a has gathered attention of headache scientists because of its apparent implication on aura initiation, photophobia and cortical hyper-responsiveness related to visual motion perception. In this hypothesis-generating study, we performed an in silico analysis of gene expression in left V3a and the cerebral gyrus that harbours it (left superior occipital gyrus (lSOG)) searching for transcriptomic patterns that could be linked with migraine’s pathophysiology. Materials and methods: Neurotransmitter receptor gene expression levels in left V3a were extracted from validated brain mRNA expression models using a probabilistic volumetric mask of this region. The primary visual cortex and other sensory cortices (auditory, olfactory and somatosensory) were used as comparators. Genome-wide transcriptomic differences between the gyrus harbouring left V3a (lSOG) and the rest of the cerebral cortex were assessed using the Allen Brain Institute Human RNA micro array atlas/database. Results: Adrenergic receptor β1, dopaminergic receptor D3 and serotoninergic receptors 1B, 1F and 2A, which have been previously implicated in migraine’s pathophysiology and/or treatment, showed significantly higher expression levels on left V3a. Transcriptomic differences between the lSOG harbouring V3a and the rest of the cortex comprise genes whose products are involved in neuronal excitability (SLC17A6, KCNS1, KCNG1 and GABRQ), activation of multiple signal transduction pathways (MET) and cell metabolism (SPHKAP via its interaction with cAMP-dependent protein kinase). Conclusions: Focal gene expression analysis of V3a suggests some clues about its implication in migraine. Further studies are warranted. |
| first_indexed | 2024-12-19T15:12:23Z |
| format | Article |
| id | doaj.art-5942d147d0ba436e85dcca91a855d061 |
| institution | Directory Open Access Journal |
| issn | 2515-8163 |
| language | English |
| last_indexed | 2024-12-19T15:12:23Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cephalalgia Reports |
| spelling | doaj.art-5942d147d0ba436e85dcca91a855d0612022-12-21T20:16:16ZengSAGE PublishingCephalalgia Reports2515-81632020-10-01310.1177/2515816320964405In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraineMarco Lisicki0Mariela Carpinella1Gianluca Coppola2Tatiana Castro Zamparella3Emiliano Ruiz-Romagnoli4Maïté Manise5Alain Maertens de Noordhout6Jean Schoenen7Diego Conci Magris8 Neuroscience Unit, Conci·Carpinella Institute, Córdoba, Argentina Neuroscience Unit, Conci·Carpinella Institute, Córdoba, Argentina Department of Medico-Surgical Sciences and Biotechnologies, Sapienza , Latina, Italy Neuroscience Unit, Conci·Carpinella Institute, Córdoba, Argentina , Buenos Aires, Argentina Headache Research Unit, University Department of Neurology – CHR Citadelle, , Liège, Belgium Headache Research Unit, University Department of Neurology – CHR Citadelle, , Liège, Belgium Headache Research Unit, University Department of Neurology – CHR Citadelle, , Liège, Belgium Neuroscience Unit, Conci·Carpinella Institute, Córdoba, ArgentinaIntroduction: Visual manifestations are the most prominent non-painful features of migraine. During the last decades, visual area V3a has gathered attention of headache scientists because of its apparent implication on aura initiation, photophobia and cortical hyper-responsiveness related to visual motion perception. In this hypothesis-generating study, we performed an in silico analysis of gene expression in left V3a and the cerebral gyrus that harbours it (left superior occipital gyrus (lSOG)) searching for transcriptomic patterns that could be linked with migraine’s pathophysiology. Materials and methods: Neurotransmitter receptor gene expression levels in left V3a were extracted from validated brain mRNA expression models using a probabilistic volumetric mask of this region. The primary visual cortex and other sensory cortices (auditory, olfactory and somatosensory) were used as comparators. Genome-wide transcriptomic differences between the gyrus harbouring left V3a (lSOG) and the rest of the cerebral cortex were assessed using the Allen Brain Institute Human RNA micro array atlas/database. Results: Adrenergic receptor β1, dopaminergic receptor D3 and serotoninergic receptors 1B, 1F and 2A, which have been previously implicated in migraine’s pathophysiology and/or treatment, showed significantly higher expression levels on left V3a. Transcriptomic differences between the lSOG harbouring V3a and the rest of the cortex comprise genes whose products are involved in neuronal excitability (SLC17A6, KCNS1, KCNG1 and GABRQ), activation of multiple signal transduction pathways (MET) and cell metabolism (SPHKAP via its interaction with cAMP-dependent protein kinase). Conclusions: Focal gene expression analysis of V3a suggests some clues about its implication in migraine. Further studies are warranted.https://doi.org/10.1177/2515816320964405 |
| spellingShingle | Marco Lisicki Mariela Carpinella Gianluca Coppola Tatiana Castro Zamparella Emiliano Ruiz-Romagnoli Maïté Manise Alain Maertens de Noordhout Jean Schoenen Diego Conci Magris In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine Cephalalgia Reports |
| title | In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine |
| title_full | In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine |
| title_fullStr | In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine |
| title_full_unstemmed | In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine |
| title_short | In silico analysis of gene expression in V3a and the superior occipital gyrus: Relevance for migraine |
| title_sort | in silico analysis of gene expression in v3a and the superior occipital gyrus relevance for migraine |
| url | https://doi.org/10.1177/2515816320964405 |
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