Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

ABSTRACT In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite. Cobalamin riboswitches are a potenti...

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Bibliographic Details
Main Authors: Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina V. Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
Bacillus subtilis
RNA biology
cobalamin
coenzyme
cofactor
corrinoid
Online Access:https://journals.asm.org/doi/10.1128/mbio.01121-22

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