Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis of the database from the international randomized controlled c...

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Bibliographic Details
Main Authors: Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L. Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A. Claus, Sina M. Coldewey, Josef Briegel, Evangelos J. Giamarellos-Bourboulis, Didier Keh, Michael Bauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
sepsis
hydrocortisone
immune therapy
machine learning
theranostics
steroids
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.607217/full

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