Etiology of super-enhancer reprogramming and activation in cancer
Abstract Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer landscape. These aberrant super-enhancers commonly form to activate proto-oncogenes, or other genes upon which ca...
Main Authors: | Royce W. Zhou, Ramon E. Parsons |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-07-01
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Series: | Epigenetics & Chromatin |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13072-023-00502-w |
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