Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs
Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-03-01
|
| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169116303744 |
| _version_ | 1819263189293989888 |
|---|---|
| author | Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban |
| author_facet | Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban |
| author_sort | Nabil Abdel Salam Ahmed Hasona |
| collection | DOAJ |
| description | Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs.
Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured.
Results: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters studied.
Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs. |
| first_indexed | 2024-12-23T20:09:38Z |
| format | Article |
| id | doaj.art-5946aac7cbfa45ccbe1bddb0e2e7d394 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-23T20:09:38Z |
| publishDate | 2017-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-5946aac7cbfa45ccbe1bddb0e2e7d3942022-12-21T17:32:51ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912017-03-017323423910.1016/j.apjtb.2016.12.004Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigsNabil Abdel Salam Ahmed Hasona0Mohammed Ahmed Qumani1Turki Ahmed Alghassab2Muath Abdulrahman Alghassab3Abdullah Ali Alghabban4Department of Biochemistry, College of Medicine, Ha'il University, Ha'il, Saudi ArabiaDepartment of Pharmacology, College of Medicine, Ha'il University, Ha'il, Saudi ArabiaDepartment of Biochemistry, College of Medicine, Ha'il University, Ha'il, Saudi ArabiaDepartment of Biochemistry, College of Medicine, Ha'il University, Ha'il, Saudi ArabiaDepartment of Biochemistry, College of Medicine, Ha'il University, Ha'il, Saudi ArabiaObjective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured. Results: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters studied. Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.http://www.sciencedirect.com/science/article/pii/S2221169116303744DiabetesIranianTrigonella foenum-graecumSeedsPunica granatumPeelStreptozotocin |
| spellingShingle | Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs Asian Pacific Journal of Tropical Biomedicine Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin |
| title | Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
| title_full | Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
| title_fullStr | Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
| title_full_unstemmed | Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
| title_short | Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
| title_sort | ameliorative properties of iranian trigonella foenum graecum l seeds and punica granatum l peel extracts in streptozotocin induced experimental diabetic guinea pigs |
| topic | Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin |
| url | http://www.sciencedirect.com/science/article/pii/S2221169116303744 |
| work_keys_str_mv | AT nabilabdelsalamahmedhasona ameliorativepropertiesofiraniantrigonellafoenumgraecumlseedsandpunicagranatumlpeelextractsinstreptozotocininducedexperimentaldiabeticguineapigs AT mohammedahmedqumani ameliorativepropertiesofiraniantrigonellafoenumgraecumlseedsandpunicagranatumlpeelextractsinstreptozotocininducedexperimentaldiabeticguineapigs AT turkiahmedalghassab ameliorativepropertiesofiraniantrigonellafoenumgraecumlseedsandpunicagranatumlpeelextractsinstreptozotocininducedexperimentaldiabeticguineapigs AT muathabdulrahmanalghassab ameliorativepropertiesofiraniantrigonellafoenumgraecumlseedsandpunicagranatumlpeelextractsinstreptozotocininducedexperimentaldiabeticguineapigs AT abdullahalialghabban ameliorativepropertiesofiraniantrigonellafoenumgraecumlseedsandpunicagranatumlpeelextractsinstreptozotocininducedexperimentaldiabeticguineapigs |