Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients.
<h4>Introduction</h4>31-77% of patients with COPD have vitamin D deficiency and insufficiency, with results being highly variable between studies. Vitamin D may also correlate with disease characteristics.<h4>Aim</h4>To find out the prevalence of vitamin D deficiency and insu...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0129080 |
| _version_ | 1818589546405691392 |
|---|---|
| author | Evgeni Mekov Yanina Slavova Adelina Tsakova Marianka Genova Dimitar Kostadinov Delcho Minchev Dora Marinova Maya Tafradjiiska |
| author_facet | Evgeni Mekov Yanina Slavova Adelina Tsakova Marianka Genova Dimitar Kostadinov Delcho Minchev Dora Marinova Maya Tafradjiiska |
| author_sort | Evgeni Mekov |
| collection | DOAJ |
| description | <h4>Introduction</h4>31-77% of patients with COPD have vitamin D deficiency and insufficiency, with results being highly variable between studies. Vitamin D may also correlate with disease characteristics.<h4>Aim</h4>To find out the prevalence of vitamin D deficiency and insufficiency in patients with COPD admitted for exacerbation and a risk factors for lower vitamin D levels among comorbidities and COPD characteristics.<h4>Methods</h4>152 patients were studied for vitamin D serum levels (25(OH)D). All of them were also assessed for diabetes mellitus (DM) and metabolic syndrome (MS). Data were gathered also for smoking status and exacerbations in last year. All patients completed CAT and mMRC questionnaires and underwent spirometry.<h4>Results</h4>A total of 83,6% of patients have reduced levels of vitamin D. 42,8% (65/152) have vitamin D insufficiency (defined as 25-50 nmol/L) and 40,8% (62/152) have vitamin D deficiency (<25 nmol/L). The mean level of 25(OH)D for all patients is 31,97 nmol/L (95%CI 29,12-34,68). Vitamin D deficiency and insufficiency are more prevalent in females vs. males (97,7 vs 77,8%; p = 0.003). The prevalence and severity of vitamin D deficiency and insufficiency in this study is significantly higher when compared to an unselected Bulgarian population (prevalence 75,8%; mean level 38,75 nmol/L). Vitamin D levels correlate with quality of life (measured by the mMRC scale) and lung function (FVC, FEV1, FEV6, FEF2575, FEV3, but not with FEV1/FVC ratio and PEF), it does not correlate with the presence of arterial hypertension, DM, MS and number of moderate, severe and total exacerbations. Vitamin D deficiency is a risk factor for longer hospital stay.<h4>Conclusions</h4>The patients with COPD admitted for exacerbation are a risk group for vitamin D deficiency and insufficiency, which is associated with worse disease characteristics. |
| first_indexed | 2024-12-16T09:42:22Z |
| format | Article |
| id | doaj.art-5946d2ff61c943b48a9309c8c12dcc20 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T09:42:22Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5946d2ff61c943b48a9309c8c12dcc202022-12-21T22:36:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012908010.1371/journal.pone.0129080Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients.Evgeni MekovYanina SlavovaAdelina TsakovaMarianka GenovaDimitar KostadinovDelcho MinchevDora MarinovaMaya Tafradjiiska<h4>Introduction</h4>31-77% of patients with COPD have vitamin D deficiency and insufficiency, with results being highly variable between studies. Vitamin D may also correlate with disease characteristics.<h4>Aim</h4>To find out the prevalence of vitamin D deficiency and insufficiency in patients with COPD admitted for exacerbation and a risk factors for lower vitamin D levels among comorbidities and COPD characteristics.<h4>Methods</h4>152 patients were studied for vitamin D serum levels (25(OH)D). All of them were also assessed for diabetes mellitus (DM) and metabolic syndrome (MS). Data were gathered also for smoking status and exacerbations in last year. All patients completed CAT and mMRC questionnaires and underwent spirometry.<h4>Results</h4>A total of 83,6% of patients have reduced levels of vitamin D. 42,8% (65/152) have vitamin D insufficiency (defined as 25-50 nmol/L) and 40,8% (62/152) have vitamin D deficiency (<25 nmol/L). The mean level of 25(OH)D for all patients is 31,97 nmol/L (95%CI 29,12-34,68). Vitamin D deficiency and insufficiency are more prevalent in females vs. males (97,7 vs 77,8%; p = 0.003). The prevalence and severity of vitamin D deficiency and insufficiency in this study is significantly higher when compared to an unselected Bulgarian population (prevalence 75,8%; mean level 38,75 nmol/L). Vitamin D levels correlate with quality of life (measured by the mMRC scale) and lung function (FVC, FEV1, FEV6, FEF2575, FEV3, but not with FEV1/FVC ratio and PEF), it does not correlate with the presence of arterial hypertension, DM, MS and number of moderate, severe and total exacerbations. Vitamin D deficiency is a risk factor for longer hospital stay.<h4>Conclusions</h4>The patients with COPD admitted for exacerbation are a risk group for vitamin D deficiency and insufficiency, which is associated with worse disease characteristics.https://doi.org/10.1371/journal.pone.0129080 |
| spellingShingle | Evgeni Mekov Yanina Slavova Adelina Tsakova Marianka Genova Dimitar Kostadinov Delcho Minchev Dora Marinova Maya Tafradjiiska Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. PLoS ONE |
| title | Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. |
| title_full | Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. |
| title_fullStr | Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. |
| title_full_unstemmed | Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. |
| title_short | Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. |
| title_sort | vitamin d deficiency and insufficiency in hospitalized copd patients |
| url | https://doi.org/10.1371/journal.pone.0129080 |
| work_keys_str_mv | AT evgenimekov vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT yaninaslavova vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT adelinatsakova vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT mariankagenova vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT dimitarkostadinov vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT delchominchev vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT doramarinova vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients AT mayatafradjiiska vitaminddeficiencyandinsufficiencyinhospitalizedcopdpatients |