The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review
Pancreatic cancer is one of the most lethal malignancies in the world. Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression. Fibroblast activation protein that is expressed in specific subtypes of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2022-06-01
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| Series: | Journal of Pancreatology |
| Online Access: | http://journals.lww.com/10.1097/JP9.0000000000000090 |
| _version_ | 1797988140064964608 |
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| author | Meixi Liu Marcus Hacker Li Huo Xiang Li |
| author_facet | Meixi Liu Marcus Hacker Li Huo Xiang Li |
| author_sort | Meixi Liu |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most lethal malignancies in the world. Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression. Fibroblast activation protein that is expressed in specific subtypes of cancer-associated fibroblasts promotes tumor growth and is related to poor survival. Recent researches have preliminarily demonstrated a promising potential of radiopharmaceuticals targeting fibroblast activation protein in diagnosis and therapy of pancreatic cancer. This article comprehensively reviews the current development and clinical translation of fibroblast activation protein inhibitor-targeting radiopharmaceuticals in pancreatic cancer and provides significant perspectives for future investigations. |
| first_indexed | 2024-04-11T07:59:04Z |
| format | Article |
| id | doaj.art-59475349fdb548839c308e84826c6495 |
| institution | Directory Open Access Journal |
| issn | 2096-5664 |
| language | English |
| last_indexed | 2024-04-11T07:59:04Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Journal of Pancreatology |
| spelling | doaj.art-59475349fdb548839c308e84826c64952022-12-22T04:35:48ZengWolters Kluwer Health/LWWJournal of Pancreatology2096-56642022-06-0152788610.1097/JP9.0000000000000090202206000-00004The application of FAPI-targeted theranostics in pancreatic cancer: a narrative reviewMeixi Liu0Marcus Hacker1Li Huo2Xiang Li3a The Nuclear Medicine Department, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Chinab Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austriaa The Nuclear Medicine Department, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Chinab Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaPancreatic cancer is one of the most lethal malignancies in the world. Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression. Fibroblast activation protein that is expressed in specific subtypes of cancer-associated fibroblasts promotes tumor growth and is related to poor survival. Recent researches have preliminarily demonstrated a promising potential of radiopharmaceuticals targeting fibroblast activation protein in diagnosis and therapy of pancreatic cancer. This article comprehensively reviews the current development and clinical translation of fibroblast activation protein inhibitor-targeting radiopharmaceuticals in pancreatic cancer and provides significant perspectives for future investigations.http://journals.lww.com/10.1097/JP9.0000000000000090 |
| spellingShingle | Meixi Liu Marcus Hacker Li Huo Xiang Li The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review Journal of Pancreatology |
| title | The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review |
| title_full | The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review |
| title_fullStr | The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review |
| title_full_unstemmed | The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review |
| title_short | The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review |
| title_sort | application of fapi targeted theranostics in pancreatic cancer a narrative review |
| url | http://journals.lww.com/10.1097/JP9.0000000000000090 |
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