Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients
Abstract Introduction Pharmacist-driven (PD) dosing and monitoring services have been shown to improve the clinical and economic outcomes in patients treated with different antibiotics, other than teicoplanin. This study investigates the impact of PD dosing and monitoring services on the clinical an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-05-01
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| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-023-00812-2 |
| _version_ | 1797795577296060416 |
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| author | Dayu Chen Bo Wen Xuanyu Wu Xinxin Zheng Huaijun Zhu Xingkai Chen Dan Han Jinchun Liu Yunxing Liu Jiayue Guo Shaoshi Zhu Haozhen Ren Weihong Ge Haixia Zhang |
| author_facet | Dayu Chen Bo Wen Xuanyu Wu Xinxin Zheng Huaijun Zhu Xingkai Chen Dan Han Jinchun Liu Yunxing Liu Jiayue Guo Shaoshi Zhu Haozhen Ren Weihong Ge Haixia Zhang |
| author_sort | Dayu Chen |
| collection | DOAJ |
| description | Abstract Introduction Pharmacist-driven (PD) dosing and monitoring services have been shown to improve the clinical and economic outcomes in patients treated with different antibiotics, other than teicoplanin. This study investigates the impact of PD dosing and monitoring services on the clinical and economic outcomes of non-critically ill patients receiving teicoplanin treatment. Methods A single-center retrospective study was conducted. Patients were divided into the PD group and the non-PD (NPD) group. Primary outcomes included the achievement of target serum concentration, and a composite endpoint of all-cause mortality, intensive care unit (ICU) admission, and sepsis or septic shock development during hospitalization or within 30 days of hospital admission. The cost of teicoplanin, overall medication cost, and total cost during hospital stay were also compared. Results A total of 163 patients from January to December 2019 were included and assessed. Seventy patients were assigned to the PD group and 93 to the NPD group. The PD group had a higher percentage of patients reaching the target trough concentration (54% versus 16%, p < 0.001). Around 26% of the patients in the PD group and 50% of the patients in the NPD group met the composite endpoint during their hospital stay (p = 0.002). The PD group exhibited a significantly lower incidence of sepsis or septic shock, shorter hospital stays, reduced drug costs, and lower total expenses. Conclusions Our study demonstrates that pharmacist-driven teicoplanin therapy can improve the clinical and economic outcomes for non-critically ill patients. Trial registration: https://www.chictr.org.cn ; identifier, ChiCTR2000033521. |
| first_indexed | 2024-03-13T03:20:03Z |
| format | Article |
| id | doaj.art-594aebdb2e554faa8093aa5809a24013 |
| institution | Directory Open Access Journal |
| issn | 2193-8229 2193-6382 |
| language | English |
| last_indexed | 2024-03-13T03:20:03Z |
| publishDate | 2023-05-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj.art-594aebdb2e554faa8093aa5809a240132023-06-25T11:23:35ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822023-05-011261579159210.1007/s40121-023-00812-2Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill PatientsDayu Chen0Bo Wen1Xuanyu Wu2Xinxin Zheng3Huaijun Zhu4Xingkai Chen5Dan Han6Jinchun Liu7Yunxing Liu8Jiayue Guo9Shaoshi Zhu10Haozhen Ren11Weihong Ge12Haixia Zhang13Department of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Burns and Plastic Surgery, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolCollege of Medicine, The University of IllinoisDepartment of Hepatobiliary Surgery, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolDepartment of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolAbstract Introduction Pharmacist-driven (PD) dosing and monitoring services have been shown to improve the clinical and economic outcomes in patients treated with different antibiotics, other than teicoplanin. This study investigates the impact of PD dosing and monitoring services on the clinical and economic outcomes of non-critically ill patients receiving teicoplanin treatment. Methods A single-center retrospective study was conducted. Patients were divided into the PD group and the non-PD (NPD) group. Primary outcomes included the achievement of target serum concentration, and a composite endpoint of all-cause mortality, intensive care unit (ICU) admission, and sepsis or septic shock development during hospitalization or within 30 days of hospital admission. The cost of teicoplanin, overall medication cost, and total cost during hospital stay were also compared. Results A total of 163 patients from January to December 2019 were included and assessed. Seventy patients were assigned to the PD group and 93 to the NPD group. The PD group had a higher percentage of patients reaching the target trough concentration (54% versus 16%, p < 0.001). Around 26% of the patients in the PD group and 50% of the patients in the NPD group met the composite endpoint during their hospital stay (p = 0.002). The PD group exhibited a significantly lower incidence of sepsis or septic shock, shorter hospital stays, reduced drug costs, and lower total expenses. Conclusions Our study demonstrates that pharmacist-driven teicoplanin therapy can improve the clinical and economic outcomes for non-critically ill patients. Trial registration: https://www.chictr.org.cn ; identifier, ChiCTR2000033521.https://doi.org/10.1007/s40121-023-00812-2TeicoplaninClinical pharmacistPharmaceutical careTherapeutic drug monitoringMRSANon-critically ill patients |
| spellingShingle | Dayu Chen Bo Wen Xuanyu Wu Xinxin Zheng Huaijun Zhu Xingkai Chen Dan Han Jinchun Liu Yunxing Liu Jiayue Guo Shaoshi Zhu Haozhen Ren Weihong Ge Haixia Zhang Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients Infectious Diseases and Therapy Teicoplanin Clinical pharmacist Pharmaceutical care Therapeutic drug monitoring MRSA Non-critically ill patients |
| title | Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients |
| title_full | Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients |
| title_fullStr | Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients |
| title_full_unstemmed | Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients |
| title_short | Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients |
| title_sort | pharmacist driven dosing services and pharmaceutical care increase probability of teicoplanin target concentration attainment and improve clinical and economic outcomes in non critically ill patients |
| topic | Teicoplanin Clinical pharmacist Pharmaceutical care Therapeutic drug monitoring MRSA Non-critically ill patients |
| url | https://doi.org/10.1007/s40121-023-00812-2 |
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