Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis
BackgroundThe implementation of indocyanine green (ICG) tracer-guided lymph node dissection is still in the preliminary stages of laparoscopic surgery, and its safety and efficacy for gastric cancer remain unclear.MethodsA systematic review was conducted in PubMed, Embase, Web of Science, the Cochra...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.884011/full |
| _version_ | 1818491128887902208 |
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| author | Jixiang Zhao Ke Li Ke Li Zikang Wang Zikang Wang Qingqing Ke Jiapu Li Yizhen Zhang Xiaojiang Zhou Yunzhi Zou Yunzhi Zou Conghua Song |
| author_facet | Jixiang Zhao Ke Li Ke Li Zikang Wang Zikang Wang Qingqing Ke Jiapu Li Yizhen Zhang Xiaojiang Zhou Yunzhi Zou Yunzhi Zou Conghua Song |
| author_sort | Jixiang Zhao |
| collection | DOAJ |
| description | BackgroundThe implementation of indocyanine green (ICG) tracer-guided lymph node dissection is still in the preliminary stages of laparoscopic surgery, and its safety and efficacy for gastric cancer remain unclear.MethodsA systematic review was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and Scopus to identify relevant subjects from inception to June 2022. The core indicators were the total number of harvested lymph nodes and the safety of the laparoscopic gastrectomy with ICG. A meta-analysis was performed to estimate the pooled weighted mean difference (WMD) and 95% confidence interval (CI).ResultsThirteen studies and 2,027 participants were included (642 for the ICG-group and 1,385 for the non-ICG group). The mean number of lymph nodes dissected in the ICG group was significantly greater than that in the non-ICG group (WMD = 6.24, 95% CI: 4.26 to 8.22, P <0.001). However, there was no significant difference in the mean number of positive lymph nodes dissected between the ICG and the non-ICG groups (WMD = 0.18, 95% CI: −0.70 to 1.07, P = 0.879). Additionally, ICG gastrectomy did not increase the risk in terms of the operative time, estimated blood loss, and postoperative complications.ConclusionICG tracer with favorable safety increases the number of harvested lymph nodes but not the number of positive lymph nodes in laparoscopic gastrectomy. More high-quality, large-sample-size randomized controlled trials are still needed to enhance this evidence. |
| first_indexed | 2024-12-10T17:26:17Z |
| format | Article |
| id | doaj.art-594f9e8ce22a453fa5c8084604c66268 |
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| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T17:26:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-594f9e8ce22a453fa5c8084604c662682022-12-22T01:39:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.884011884011Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysisJixiang Zhao0Ke Li1Ke Li2Zikang Wang3Zikang Wang4Qingqing Ke5Jiapu Li6Yizhen Zhang7Xiaojiang Zhou8Yunzhi Zou9Yunzhi Zou10Conghua Song11Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Surgical Oncology, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterolog, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Surgical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Gastroenterology, The Affiliated Hospital (Group) of Putian University, Putian, ChinaBackgroundThe implementation of indocyanine green (ICG) tracer-guided lymph node dissection is still in the preliminary stages of laparoscopic surgery, and its safety and efficacy for gastric cancer remain unclear.MethodsA systematic review was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and Scopus to identify relevant subjects from inception to June 2022. The core indicators were the total number of harvested lymph nodes and the safety of the laparoscopic gastrectomy with ICG. A meta-analysis was performed to estimate the pooled weighted mean difference (WMD) and 95% confidence interval (CI).ResultsThirteen studies and 2,027 participants were included (642 for the ICG-group and 1,385 for the non-ICG group). The mean number of lymph nodes dissected in the ICG group was significantly greater than that in the non-ICG group (WMD = 6.24, 95% CI: 4.26 to 8.22, P <0.001). However, there was no significant difference in the mean number of positive lymph nodes dissected between the ICG and the non-ICG groups (WMD = 0.18, 95% CI: −0.70 to 1.07, P = 0.879). Additionally, ICG gastrectomy did not increase the risk in terms of the operative time, estimated blood loss, and postoperative complications.ConclusionICG tracer with favorable safety increases the number of harvested lymph nodes but not the number of positive lymph nodes in laparoscopic gastrectomy. More high-quality, large-sample-size randomized controlled trials are still needed to enhance this evidence.https://www.frontiersin.org/articles/10.3389/fonc.2022.884011/fullindocyanine greenlaparoscopic gastrectomygastric cancerefficacysafety |
| spellingShingle | Jixiang Zhao Ke Li Ke Li Zikang Wang Zikang Wang Qingqing Ke Jiapu Li Yizhen Zhang Xiaojiang Zhou Yunzhi Zou Yunzhi Zou Conghua Song Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis Frontiers in Oncology indocyanine green laparoscopic gastrectomy gastric cancer efficacy safety |
| title | Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis |
| title_full | Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis |
| title_short | Efficacy and safety of indocyanine green tracer-guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer: A systematic review and meta-analysis |
| title_sort | efficacy and safety of indocyanine green tracer guided lymph node dissection in minimally invasive radical gastrectomy for gastric cancer a systematic review and meta analysis |
| topic | indocyanine green laparoscopic gastrectomy gastric cancer efficacy safety |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.884011/full |
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