Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance
Antibiotics are emerging pollutants that have detrimental effects on both target and non-target organisms in the environment. However, current methods for environmental risk assessment primarily focus on the risk to non-target organisms in ecosystems, overlooking a crucial risk of antibiotics - the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023004130 |
| _version_ | 1797683198938841088 |
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| author | Feifei Li Yingyu Bao Lyujun Chen Zhiguo Su Yushi Tang Donghui Wen |
| author_facet | Feifei Li Yingyu Bao Lyujun Chen Zhiguo Su Yushi Tang Donghui Wen |
| author_sort | Feifei Li |
| collection | DOAJ |
| description | Antibiotics are emerging pollutants that have detrimental effects on both target and non-target organisms in the environment. However, current methods for environmental risk assessment primarily focus on the risk to non-target organisms in ecosystems, overlooking a crucial risk of antibiotics - the induction of resistance in targeted bacteria. To address this oversight, we have incorporated resistance (R) risk with persistence, bioaccumulation and toxicity (PBT) to establish a more comprehensive PBTR (persistence, bioaccumulation, toxicity, and resistance) framework for antibiotic-specific risk assessment. Using the PBTR framework, we evaluated 74 antibiotics detected in Chinese seawater from 2000 to 2021, and identified priority antibiotics. Our analysis revealed that the priority antibiotics with R risk accounted for the largest proportion (50% to 70%), followed by P risk (40% to 58%), T risk (16% to 35%) and B risk (0 to 13%). To further categorize these priority antibiotics, we assigned them a risk level according to their fulfillment of criteria related to P, B, T, and R. Antibiotics meeting all four indicators were classified as Grade I, representing the highest risk level. Grade II and Grade III were assigned to antibiotics meeting three or two indicators, respectively. Antibiotics meeting only one indicator were classified as Grade IV, representing the lowest risk level. The majority of priority antibiotics fell into Grade IV, indicating low risk (55% to 79%), followed by Grade III (16% to 45%). The highest risk antibiotic identified in this study was clindamycin (CLIN), categorized as Grade II, in the East China Sea. Our findings aligned with previous studies for 25 antibiotics, affirming the validity of the PBTR framework. Moreover, we identified 13 new priority antibiotics, highlighting the advancement of this approach. This study provides a feasible screening strategy and monitoring recommendations for priority antibiotics in Chinese seawater. |
| first_indexed | 2024-03-12T00:11:05Z |
| format | Article |
| id | doaj.art-59502f4a8fd347d1b33b3cd0ba648ffb |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-12T00:11:05Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-59502f4a8fd347d1b33b3cd0ba648ffb2023-09-16T05:28:41ZengElsevierEnvironment International0160-41202023-09-01179108140Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistanceFeifei Li0Yingyu Bao1Lyujun Chen2Zhiguo Su3Yushi Tang4Donghui Wen5School of Environment, Tsinghua University, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, ChinaCollege of Environmental Sciences and Engineering, Peking University, ChinaSchool of Environment, Tsinghua University, ChinaSchool of Environment, Tsinghua University, ChinaLewis-Sigler Institute for Integrative Genomics, Princeton University, USACollege of Environmental Sciences and Engineering, Peking University, China; Corresponding author at: College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.Antibiotics are emerging pollutants that have detrimental effects on both target and non-target organisms in the environment. However, current methods for environmental risk assessment primarily focus on the risk to non-target organisms in ecosystems, overlooking a crucial risk of antibiotics - the induction of resistance in targeted bacteria. To address this oversight, we have incorporated resistance (R) risk with persistence, bioaccumulation and toxicity (PBT) to establish a more comprehensive PBTR (persistence, bioaccumulation, toxicity, and resistance) framework for antibiotic-specific risk assessment. Using the PBTR framework, we evaluated 74 antibiotics detected in Chinese seawater from 2000 to 2021, and identified priority antibiotics. Our analysis revealed that the priority antibiotics with R risk accounted for the largest proportion (50% to 70%), followed by P risk (40% to 58%), T risk (16% to 35%) and B risk (0 to 13%). To further categorize these priority antibiotics, we assigned them a risk level according to their fulfillment of criteria related to P, B, T, and R. Antibiotics meeting all four indicators were classified as Grade I, representing the highest risk level. Grade II and Grade III were assigned to antibiotics meeting three or two indicators, respectively. Antibiotics meeting only one indicator were classified as Grade IV, representing the lowest risk level. The majority of priority antibiotics fell into Grade IV, indicating low risk (55% to 79%), followed by Grade III (16% to 45%). The highest risk antibiotic identified in this study was clindamycin (CLIN), categorized as Grade II, in the East China Sea. Our findings aligned with previous studies for 25 antibiotics, affirming the validity of the PBTR framework. Moreover, we identified 13 new priority antibiotics, highlighting the advancement of this approach. This study provides a feasible screening strategy and monitoring recommendations for priority antibiotics in Chinese seawater.http://www.sciencedirect.com/science/article/pii/S0160412023004130Priority antibioticsResistanceEnvironment risk assessmentPBTR frameworkSeawater |
| spellingShingle | Feifei Li Yingyu Bao Lyujun Chen Zhiguo Su Yushi Tang Donghui Wen Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance Environment International Priority antibiotics Resistance Environment risk assessment PBTR framework Seawater |
| title | Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance |
| title_full | Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance |
| title_fullStr | Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance |
| title_full_unstemmed | Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance |
| title_short | Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance |
| title_sort | screening of priority antibiotics in chinese seawater based on the persistence bioaccumulation toxicity and resistance |
| topic | Priority antibiotics Resistance Environment risk assessment PBTR framework Seawater |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023004130 |
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