Skin wound healing effects of (+)-syringaresinol from ginseng berry
Background: Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Ginseng Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845323000325 |
| _version_ | 1797733061921603584 |
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| author | Jee-hyun Hwang Yeonsoo Kang Heui-Jin Park Seolyeong Kim Su-Hyun Lee Hangun Kim Sang-Jip Nam Kyung-Min Lim |
| author_facet | Jee-hyun Hwang Yeonsoo Kang Heui-Jin Park Seolyeong Kim Su-Hyun Lee Hangun Kim Sang-Jip Nam Kyung-Min Lim |
| author_sort | Jee-hyun Hwang |
| collection | DOAJ |
| description | Background: Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects on the skin have been recently reported. However, little is known about the its effects on the wound healing process of skin. Methods: Here, we evaluated the skin wound healing effect of (+)-SYR using the human fibroblast Hs68 cell and ex vivo pig and human skin tissue model. Scratch wound test and hydrogen peroxide (HPO) induce chemical wound model were employed. Results: (+)-SYR promoted the migration and proliferation of Hs68 cells without significant cytotoxicity at the tested concentrations. Especially, in ex vivo pig and human skin tissue, HPO-induced chemical wound was recovered almost completely by (+)-SYR. In line with the finding in Hs68, the protein expression levels of TGF-β and PCNA, a proliferation marker were increased, demonstrating the beneficial effects of (+)-SYR on skin wound repair. Conclusion: Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair. |
| first_indexed | 2024-03-12T12:23:37Z |
| format | Article |
| id | doaj.art-5950666751524a7fbe9e1958b9f32402 |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-03-12T12:23:37Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-5950666751524a7fbe9e1958b9f324022023-08-30T05:50:08ZengElsevierJournal of Ginseng Research1226-84532023-09-01475654661Skin wound healing effects of (+)-syringaresinol from ginseng berryJee-hyun Hwang0Yeonsoo Kang1Heui-Jin Park2Seolyeong Kim3Su-Hyun Lee4Hangun Kim5Sang-Jip Nam6Kyung-Min Lim7College of Pharmacy, Ewha Womans University, Seoul, Republic of KoreaCollege of Pharmacy, Ewha Womans University, Seoul, Republic of KoreaCollege of Pharmacy, Ewha Womans University, Seoul, Republic of KoreaBiosolution Co, Seoul, Republic of KoreaBiosolution Co, Seoul, Republic of KoreaCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Republic of KoreaDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea; Corresponding author. College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea.College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea; Corresponding author. College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea.Background: Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects on the skin have been recently reported. However, little is known about the its effects on the wound healing process of skin. Methods: Here, we evaluated the skin wound healing effect of (+)-SYR using the human fibroblast Hs68 cell and ex vivo pig and human skin tissue model. Scratch wound test and hydrogen peroxide (HPO) induce chemical wound model were employed. Results: (+)-SYR promoted the migration and proliferation of Hs68 cells without significant cytotoxicity at the tested concentrations. Especially, in ex vivo pig and human skin tissue, HPO-induced chemical wound was recovered almost completely by (+)-SYR. In line with the finding in Hs68, the protein expression levels of TGF-β and PCNA, a proliferation marker were increased, demonstrating the beneficial effects of (+)-SYR on skin wound repair. Conclusion: Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.http://www.sciencedirect.com/science/article/pii/S1226845323000325(+)-SyringaresinolPanax ginsengGinseng berryWound healing |
| spellingShingle | Jee-hyun Hwang Yeonsoo Kang Heui-Jin Park Seolyeong Kim Su-Hyun Lee Hangun Kim Sang-Jip Nam Kyung-Min Lim Skin wound healing effects of (+)-syringaresinol from ginseng berry Journal of Ginseng Research (+)-Syringaresinol Panax ginseng Ginseng berry Wound healing |
| title | Skin wound healing effects of (+)-syringaresinol from ginseng berry |
| title_full | Skin wound healing effects of (+)-syringaresinol from ginseng berry |
| title_fullStr | Skin wound healing effects of (+)-syringaresinol from ginseng berry |
| title_full_unstemmed | Skin wound healing effects of (+)-syringaresinol from ginseng berry |
| title_short | Skin wound healing effects of (+)-syringaresinol from ginseng berry |
| title_sort | skin wound healing effects of syringaresinol from ginseng berry |
| topic | (+)-Syringaresinol Panax ginseng Ginseng berry Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S1226845323000325 |
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