Track Structure-Based Simulations on DNA Damage Induced by Diverse Isotopes
Diverse isotopes such as <sup>2</sup>H, <sup>3</sup>He, <sup>10</sup>Be, <sup>11</sup>C and <sup>14</sup>C occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/22/13693 |
| Summary: | Diverse isotopes such as <sup>2</sup>H, <sup>3</sup>He, <sup>10</sup>Be, <sup>11</sup>C and <sup>14</sup>C occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques. However, only a few studies have specifically addressed the biological effects of diverse isotopes and were limited to energies of several MeV/u. A database of simulations with the PARTRAC biophysical tool is presented for H, He, Li, Be, B and C isotopes at energies from 0.5 GeV/u down to stopping. The doses deposited to a cell nucleus and also the yields per unit dose of single- and double-strand breaks and their clusters induced in cellular DNA are predicted to vary among diverse isotopes of the same element at energies < 1 MeV/u, especially for isotopes of H and He. The results may affect the risk estimates for astronauts in deep space missions or the models of biological effectiveness of ion beams and indicate that radiation protection in <sup>14</sup>C or <sup>10</sup>Be dating techniques may be based on knowledge gathered with <sup>12</sup>C or <sup>9</sup>Be. |
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| ISSN: | 1661-6596 1422-0067 |