Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases
Vasculogenesis and angiogenesis are physiological mechanisms occurring throughout the body. Any disruption to the precise balance of blood vessel growth necessary to support healthy tissue, and the inhibition of abnormal vessel sprouting has the potential to negatively impact stages of development a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/8/2889 |
| _version_ | 1797570103242391552 |
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| author | Pei-Li Yao Jeremy Peavey Goldis Malek |
| author_facet | Pei-Li Yao Jeremy Peavey Goldis Malek |
| author_sort | Pei-Li Yao |
| collection | DOAJ |
| description | Vasculogenesis and angiogenesis are physiological mechanisms occurring throughout the body. Any disruption to the precise balance of blood vessel growth necessary to support healthy tissue, and the inhibition of abnormal vessel sprouting has the potential to negatively impact stages of development and/or healing. Therefore, the identification of key regulators of these vascular processes is critical to identifying therapeutic means by which to target vascular-associated compromises and complications. Nuclear receptors are a family of transcription factors that have been shown to be involved in modulating different aspects of vascular biology in many tissues systems. Most recently, the role of nuclear receptors in ocular biology and vasculopathies has garnered interest. Herein, we review studies that have used in vitro assays and in vivo models to investigate nuclear receptor-driven pathways in two ocular vascular diseases associated with blindness, wet or exudative age-related macular degeneration, and proliferative diabetic retinopathy. The potential therapeutic targeting of nuclear receptors for ocular diseases is also discussed. |
| first_indexed | 2024-03-10T20:20:14Z |
| format | Article |
| id | doaj.art-595494fe8db94f00b026905b6cbb23bf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:20:14Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-595494fe8db94f00b026905b6cbb23bf2023-11-19T22:14:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218288910.3390/ijms21082889Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular DiseasesPei-Li Yao0Jeremy Peavey1Goldis Malek2Duke Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27503, USADuke Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27503, USADuke Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27503, USAVasculogenesis and angiogenesis are physiological mechanisms occurring throughout the body. Any disruption to the precise balance of blood vessel growth necessary to support healthy tissue, and the inhibition of abnormal vessel sprouting has the potential to negatively impact stages of development and/or healing. Therefore, the identification of key regulators of these vascular processes is critical to identifying therapeutic means by which to target vascular-associated compromises and complications. Nuclear receptors are a family of transcription factors that have been shown to be involved in modulating different aspects of vascular biology in many tissues systems. Most recently, the role of nuclear receptors in ocular biology and vasculopathies has garnered interest. Herein, we review studies that have used in vitro assays and in vivo models to investigate nuclear receptor-driven pathways in two ocular vascular diseases associated with blindness, wet or exudative age-related macular degeneration, and proliferative diabetic retinopathy. The potential therapeutic targeting of nuclear receptors for ocular diseases is also discussed.https://www.mdpi.com/1422-0067/21/8/2889nuclear receptorsangiogenesiswet age-related macular degenerationproliferative diabetic retinopathyinflammation |
| spellingShingle | Pei-Li Yao Jeremy Peavey Goldis Malek Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases International Journal of Molecular Sciences nuclear receptors angiogenesis wet age-related macular degeneration proliferative diabetic retinopathy inflammation |
| title | Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases |
| title_full | Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases |
| title_fullStr | Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases |
| title_full_unstemmed | Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases |
| title_short | Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases |
| title_sort | leveraging nuclear receptors as targets for pathological ocular vascular diseases |
| topic | nuclear receptors angiogenesis wet age-related macular degeneration proliferative diabetic retinopathy inflammation |
| url | https://www.mdpi.com/1422-0067/21/8/2889 |
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