Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas

Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas

Budding at the tumor invasive front has been correlated with the malignant properties of many cancers. Malic enzyme 1 (ME1) promotes the Warburg effect in cancer cells and induces epithelial–mesenchymal transition (EMT) in oral squamous cell carcinoma (OSCC). Therefore, we investigated the role of M...

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Bibliographic Details
Main Authors: Chie Nakashima, Tadaaki Kirita, Kazuhiko Yamamoto, Shiori Mori, Yi Luo, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Isao Kawahara, Takuya Mori, Kei Goto, Shingo Kishi, Rina Fujiwara-Tani, Hiroki Kuniyasu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
ME1
tumor budding
EMT
extracellular pH
hypoxia
Online Access:https://www.mdpi.com/1422-0067/21/19/7149

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