Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening

Background: There is still controversy on the importance of soft markers on the fetus and neonatal outcomes. This study aimed to determine the mentioned outcomes in the fetuses with soft markers detected by ultrasound screening. Methods: This prospective study was conducted on 461 pregnant women who...

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Main Authors: Mahboobeh Shirazi, Mona Taghavipour, Behnaz Moradi, Fatemeh Sharafi, Fatemeh Golshahi, Behrokh Sahebdel, Elham Feizabad, Maria Nezamnia, Zahra Khazaeipour, Maryam Moshfeghi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-04-01
Series:Iranian Journal of Neonatology
Subjects:
Online Access:https://ijn.mums.ac.ir/article_19960_ef17bb158f11bf67934280660fd48032.pdf
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author Mahboobeh Shirazi
Mona Taghavipour
Behnaz Moradi
Fatemeh Sharafi
Fatemeh Golshahi
Behrokh Sahebdel
Elham Feizabad
Maria Nezamnia
Zahra Khazaeipour
Maryam Moshfeghi
Fatemeh Sharafi
author_facet Mahboobeh Shirazi
Mona Taghavipour
Behnaz Moradi
Fatemeh Sharafi
Fatemeh Golshahi
Behrokh Sahebdel
Elham Feizabad
Maria Nezamnia
Zahra Khazaeipour
Maryam Moshfeghi
Fatemeh Sharafi
author_sort Mahboobeh Shirazi
collection DOAJ
description Background: There is still controversy on the importance of soft markers on the fetus and neonatal outcomes. This study aimed to determine the mentioned outcomes in the fetuses with soft markers detected by ultrasound screening. Methods: This prospective study was conducted on 461 pregnant women who were referred to the prenatal clinics of hospitals affiliated with the Tehran University of Medical Sciences, Tehran, Iran, in 2021. The study outcomes included incidence of abortion, preterm birth (PTB), cesarean section (CS), low birth weight (LBW), neonatal admission rates, and neonatal mortality. Results: The most frequent soft marker in the present study was echogenic intra-cardiac foci (EIF) (32.5%), followed by choroid plexus cyst (CPC) (30.6%), pyelectasis (25.2%), and echogenic bowel (EB) (15.8%), respectively. Spontaneous abortion, PTB, CS, LBW, neonatal department admission, neonatal intensive care unit (NICU) admission, stillbirth, and fetal distress, and death occurred in 10 (2.1%), 52 (12.5%),  316 (76%), 35 (7.6%), 28 (6.7%),  42 (10.1%), 13 (3.1%),  26 (5.6%), and one (0.24%) cases, respectively. Poor neonatal outcomes were significantly associated with EIF (P=0.007), CPC (P=0.045), echogenic bowel (P=0.031), pyelectasis (P=0.026), and single umbilical artery (P=0.010). In addition, the fetuses with synchronous CPC and IEF and also synchronous pyelectasis and IEF were at significantly higher risk of poor neonatal outcomes (P=0.037). Conclusion: The study results showed that although poor neonatal outcomes were associated with some soft markers, most fetuses with soft markers had desired outcomes in the absence of structural or chromosomal abnormality.
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spelling doaj.art-5955224726e042c7b02189e5c762ec442022-12-22T02:37:27ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582022-04-01132727810.22038/ijn.2022.62724.219719960Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound ScreeningMahboobeh Shirazi0Mona Taghavipour1Behnaz Moradi2Fatemeh Sharafi3Fatemeh Golshahi4Behrokh Sahebdel5Elham Feizabad6Maria Nezamnia7Zahra Khazaeipour8Maryam Moshfeghi9Fatemeh Sharafi10Maternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Radiology, Yas complex Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal, and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, School of Medicine, Bam University of Medical Sciences, Kerman,Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, ACECR, Tehran, IranCellular and Molecular Biology Department, Tehran Azad University of Medical Sciences, Tehran, IranBackground: There is still controversy on the importance of soft markers on the fetus and neonatal outcomes. This study aimed to determine the mentioned outcomes in the fetuses with soft markers detected by ultrasound screening. Methods: This prospective study was conducted on 461 pregnant women who were referred to the prenatal clinics of hospitals affiliated with the Tehran University of Medical Sciences, Tehran, Iran, in 2021. The study outcomes included incidence of abortion, preterm birth (PTB), cesarean section (CS), low birth weight (LBW), neonatal admission rates, and neonatal mortality. Results: The most frequent soft marker in the present study was echogenic intra-cardiac foci (EIF) (32.5%), followed by choroid plexus cyst (CPC) (30.6%), pyelectasis (25.2%), and echogenic bowel (EB) (15.8%), respectively. Spontaneous abortion, PTB, CS, LBW, neonatal department admission, neonatal intensive care unit (NICU) admission, stillbirth, and fetal distress, and death occurred in 10 (2.1%), 52 (12.5%),  316 (76%), 35 (7.6%), 28 (6.7%),  42 (10.1%), 13 (3.1%),  26 (5.6%), and one (0.24%) cases, respectively. Poor neonatal outcomes were significantly associated with EIF (P=0.007), CPC (P=0.045), echogenic bowel (P=0.031), pyelectasis (P=0.026), and single umbilical artery (P=0.010). In addition, the fetuses with synchronous CPC and IEF and also synchronous pyelectasis and IEF were at significantly higher risk of poor neonatal outcomes (P=0.037). Conclusion: The study results showed that although poor neonatal outcomes were associated with some soft markers, most fetuses with soft markers had desired outcomes in the absence of structural or chromosomal abnormality.https://ijn.mums.ac.ir/article_19960_ef17bb158f11bf67934280660fd48032.pdffetusfollow-upisolated soft markerneonataloutcomeultrasonography
spellingShingle Mahboobeh Shirazi
Mona Taghavipour
Behnaz Moradi
Fatemeh Sharafi
Fatemeh Golshahi
Behrokh Sahebdel
Elham Feizabad
Maria Nezamnia
Zahra Khazaeipour
Maryam Moshfeghi
Fatemeh Sharafi
Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
Iranian Journal of Neonatology
fetus
follow-up
isolated soft marker
neonatal
outcome
ultrasonography
title Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
title_full Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
title_fullStr Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
title_full_unstemmed Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
title_short Neonatal Outcomes of Fetuses with Isolated or Multiple Soft Markers in Ultrasound Screening
title_sort neonatal outcomes of fetuses with isolated or multiple soft markers in ultrasound screening
topic fetus
follow-up
isolated soft marker
neonatal
outcome
ultrasonography
url https://ijn.mums.ac.ir/article_19960_ef17bb158f11bf67934280660fd48032.pdf
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