Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b?
INTRODUCTION: Classification TNM 1997 defines renal cell carcinoma smaller than 7 cm and confined to the kidney as stage T1. Our goal is to discuss if tumors smaller than 4 cm have the same behavior characteristics then tumors between 4 and 7 cm, to compose the same stage of the disease. MATERIALS A...
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| Format: | Article |
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Sociedade Brasileira de Urologia
2003-04-01
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382003000200003 |
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| author | Marcos Dall’Oglio Miguel Srougi Marcelo Mangini Eduardo Ribeiro Márcio Ferraz Adriana Sañudo Kátia Leite Luciano Nesrallah |
| author_facet | Marcos Dall’Oglio Miguel Srougi Marcelo Mangini Eduardo Ribeiro Márcio Ferraz Adriana Sañudo Kátia Leite Luciano Nesrallah |
| author_sort | Marcos Dall’Oglio |
| collection | DOAJ |
| description | INTRODUCTION: Classification TNM 1997 defines renal cell carcinoma smaller than 7 cm and confined to the kidney as stage T1. Our goal is to discuss if tumors smaller than 4 cm have the same behavior characteristics then tumors between 4 and 7 cm, to compose the same stage of the disease. MATERIALS AND METHODS: Retrospective assessment of 138 patients in stage T1 (TNM - 97), divided into 2 groups; group-1: composed of 65 patients (47%) with tumors < 4 cm, and group-2: composed of 73 patients (53%) with tumors between 4 and 7 cm. The following prognostic factors were assessed in the recurrence of the disease and survival of patients: nuclear degree, microvascular invasion, sarcomatous degeneration, and involved lymph nodes. Statistical evaluation has been accomplished through the log rank test, chi-square test, and Fishers exact text. RESULTS: Average tumor size was 2.5 cm for group-1, and 5.3 cm for group-2. In group-2, there was the predominance of worse prognostic factors, with high-grade tumors (p = 0.01) and presence of microvascular invasion (p = 0.001). Sarcomatous tumors and involvement of lymph nodes did only happen in group-2. Disease-free survival for group-1, analyzed in the median period of 36 months, was 100%, and for group 2, in the median period of 31 months, was 81% (p = 0.008). CONCLUSION: The results obtained allow the conclusion that the present stage T1 for renal cell carcinoma gathers tumors of different evolution, being therefore recommendable the stratification in T1a for tumors smaller than 4 cm, and T1b for tumors between 4 and 7 cm. |
| first_indexed | 2024-12-12T10:43:56Z |
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| id | doaj.art-59555321e8ce4351b7f72f3b1ca1b992 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-12T10:43:56Z |
| publishDate | 2003-04-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-59555321e8ce4351b7f72f3b1ca1b9922022-12-22T00:26:57ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192003-04-0129210611210.1590/S1677-55382003000200003Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b?Marcos Dall’OglioMiguel SrougiMarcelo ManginiEduardo RibeiroMárcio FerrazAdriana SañudoKátia LeiteLuciano NesrallahINTRODUCTION: Classification TNM 1997 defines renal cell carcinoma smaller than 7 cm and confined to the kidney as stage T1. Our goal is to discuss if tumors smaller than 4 cm have the same behavior characteristics then tumors between 4 and 7 cm, to compose the same stage of the disease. MATERIALS AND METHODS: Retrospective assessment of 138 patients in stage T1 (TNM - 97), divided into 2 groups; group-1: composed of 65 patients (47%) with tumors < 4 cm, and group-2: composed of 73 patients (53%) with tumors between 4 and 7 cm. The following prognostic factors were assessed in the recurrence of the disease and survival of patients: nuclear degree, microvascular invasion, sarcomatous degeneration, and involved lymph nodes. Statistical evaluation has been accomplished through the log rank test, chi-square test, and Fishers exact text. RESULTS: Average tumor size was 2.5 cm for group-1, and 5.3 cm for group-2. In group-2, there was the predominance of worse prognostic factors, with high-grade tumors (p = 0.01) and presence of microvascular invasion (p = 0.001). Sarcomatous tumors and involvement of lymph nodes did only happen in group-2. Disease-free survival for group-1, analyzed in the median period of 36 months, was 100%, and for group 2, in the median period of 31 months, was 81% (p = 0.008). CONCLUSION: The results obtained allow the conclusion that the present stage T1 for renal cell carcinoma gathers tumors of different evolution, being therefore recommendable the stratification in T1a for tumors smaller than 4 cm, and T1b for tumors between 4 and 7 cm.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382003000200003kidneycarcinomarenal cellneoplasm stagingprognosisclassificationsurvival |
| spellingShingle | Marcos Dall’Oglio Miguel Srougi Marcelo Mangini Eduardo Ribeiro Márcio Ferraz Adriana Sañudo Kátia Leite Luciano Nesrallah Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? International Brazilian Journal of Urology kidney carcinoma renal cell neoplasm staging prognosis classification survival |
| title | Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? |
| title_full | Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? |
| title_fullStr | Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? |
| title_full_unstemmed | Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? |
| title_short | Assessment of stage T1 (TNM 1997) for renal cell carcinoma: is recommended the subdivision in T1a and T1b? |
| title_sort | assessment of stage t1 tnm 1997 for renal cell carcinoma is recommended the subdivision in t1a and t1b |
| topic | kidney carcinoma renal cell neoplasm staging prognosis classification survival |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382003000200003 |
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