Serum levels of MMP-7 in primary brain cancers and brain metastases
The aim of this study was to evaluate the possible role of MMP-7 serum levels as biomarkers for brain tumours. This study included 50 patients with meningiomas, other benign tumours, high-grade gliomas, brain metastases and other non-tumour diseases and 41 control individuals. The MMP-7 serum levels...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Biotechnology & Biotechnological Equipment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13102818.2019.1626282 |
| _version_ | 1818906606431109120 |
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| author | Ivelina Dimitrova Tanya Tacheva Ivan Mindov Bozhidar Petrov Elina Aleksandrova Stefan Valkanov Maya Gulubova Tatyana Vlaykova |
| author_facet | Ivelina Dimitrova Tanya Tacheva Ivan Mindov Bozhidar Petrov Elina Aleksandrova Stefan Valkanov Maya Gulubova Tatyana Vlaykova |
| author_sort | Ivelina Dimitrova |
| collection | DOAJ |
| description | The aim of this study was to evaluate the possible role of MMP-7 serum levels as biomarkers for brain tumours. This study included 50 patients with meningiomas, other benign tumours, high-grade gliomas, brain metastases and other non-tumour diseases and 41 control individuals. The MMP-7 serum levels were measured by enzyme-linked immunosorbent assay (ELISA). We significantly found higher serum levels of MMP-7 in patients with benign brain tumours (2.33 ± 0.37 [SEM] ng/mL, p = 0.006) and brain metastases (2.54 ± 0.33 ng/mL, p = 0.0001) compared to controls (1.48 ± 0.09 ng/mL). Glioblastoma (GBM) patients had serum MMP-7 levels comparable to those of the controls (1.44 ± 0.13 ng/mL, p = 0.901) but significantly lower than those of the patients with benign tumours (p = 0.018) and brain metastases (p = 0.001). In patients with benign tumours, there was a positive correlation with borderline significance between serum MMP-7 levels and leukocyte counts (ρ = 0.538, p = 0.058). No difference was found (p = 0.448, paired-samples t-test) when comparing the MMP-7 levels in the serum samples obtained at admission and 4–7 days after surgery of some of the patients (n = 7). According to our results, the MMP-7 serum levels might be a useful serum biomarker for benign brain tumours and for brain metastases but not for glioblastoma. |
| first_indexed | 2024-12-19T21:41:54Z |
| format | Article |
| id | doaj.art-595a2099dfde47c0bbe59da654f2296f |
| institution | Directory Open Access Journal |
| issn | 1310-2818 1314-3530 |
| language | English |
| last_indexed | 2024-12-19T21:41:54Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj.art-595a2099dfde47c0bbe59da654f2296f2022-12-21T20:04:38ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302019-01-0133188188510.1080/13102818.2019.16262821626282Serum levels of MMP-7 in primary brain cancers and brain metastasesIvelina Dimitrova0Tanya Tacheva1Ivan Mindov2Bozhidar Petrov3Elina Aleksandrova4Stefan Valkanov5Maya Gulubova6Tatyana Vlaykova7Trakia UniversityTrakia UniversityTrakia UniversityTrakia UniversityTrakia UniversityTrakia UniversityTrakia UniversityTrakia UniversityThe aim of this study was to evaluate the possible role of MMP-7 serum levels as biomarkers for brain tumours. This study included 50 patients with meningiomas, other benign tumours, high-grade gliomas, brain metastases and other non-tumour diseases and 41 control individuals. The MMP-7 serum levels were measured by enzyme-linked immunosorbent assay (ELISA). We significantly found higher serum levels of MMP-7 in patients with benign brain tumours (2.33 ± 0.37 [SEM] ng/mL, p = 0.006) and brain metastases (2.54 ± 0.33 ng/mL, p = 0.0001) compared to controls (1.48 ± 0.09 ng/mL). Glioblastoma (GBM) patients had serum MMP-7 levels comparable to those of the controls (1.44 ± 0.13 ng/mL, p = 0.901) but significantly lower than those of the patients with benign tumours (p = 0.018) and brain metastases (p = 0.001). In patients with benign tumours, there was a positive correlation with borderline significance between serum MMP-7 levels and leukocyte counts (ρ = 0.538, p = 0.058). No difference was found (p = 0.448, paired-samples t-test) when comparing the MMP-7 levels in the serum samples obtained at admission and 4–7 days after surgery of some of the patients (n = 7). According to our results, the MMP-7 serum levels might be a useful serum biomarker for benign brain tumours and for brain metastases but not for glioblastoma.http://dx.doi.org/10.1080/13102818.2019.1626282mmp-7brain metastasesglioblastomaastrocytoma biomarker |
| spellingShingle | Ivelina Dimitrova Tanya Tacheva Ivan Mindov Bozhidar Petrov Elina Aleksandrova Stefan Valkanov Maya Gulubova Tatyana Vlaykova Serum levels of MMP-7 in primary brain cancers and brain metastases Biotechnology & Biotechnological Equipment mmp-7 brain metastases glioblastoma astrocytoma biomarker |
| title | Serum levels of MMP-7 in primary brain cancers and brain metastases |
| title_full | Serum levels of MMP-7 in primary brain cancers and brain metastases |
| title_fullStr | Serum levels of MMP-7 in primary brain cancers and brain metastases |
| title_full_unstemmed | Serum levels of MMP-7 in primary brain cancers and brain metastases |
| title_short | Serum levels of MMP-7 in primary brain cancers and brain metastases |
| title_sort | serum levels of mmp 7 in primary brain cancers and brain metastases |
| topic | mmp-7 brain metastases glioblastoma astrocytoma biomarker |
| url | http://dx.doi.org/10.1080/13102818.2019.1626282 |
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