Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience
Stevens-Johnson syndrome (SJS), toxic-epidermal necrolysis (TEN), and SJS-TEN overlap syndrome form a continuum of rare, life-threatening disease that often warrants immediate and intensive treatment in a burn center. Our objective in this study was to determine factors associated with the prevalenc...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Burns Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468912222000116 |
| _version_ | 1818536221864886272 |
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| author | Michael J. Duplisea Carolyn M. Ziemer Sarah L. Laughon Felicia N. Williams |
| author_facet | Michael J. Duplisea Carolyn M. Ziemer Sarah L. Laughon Felicia N. Williams |
| author_sort | Michael J. Duplisea |
| collection | DOAJ |
| description | Stevens-Johnson syndrome (SJS), toxic-epidermal necrolysis (TEN), and SJS-TEN overlap syndrome form a continuum of rare, life-threatening disease that often warrants immediate and intensive treatment in a burn center. Our objective in this study was to determine factors associated with the prevalence, severity, and mortality in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) admitted to our center. We performed a retrospective analysis of 192 patients admitted to our burn center from 1 January 2009 to 31 December 2019 for SJS/TEN. Severity-of-illness Score for TEN (SCORTEN), length of stay, and inpatient mortality were analyzed. Of 192 patients, 104 (54%) were Black, 117 (61%) were female, and 39 (20%) had a pre-existing psychiatric illness. Overall, 43 (22%) patients died. Female patients had significantly longer lengths of stay, with a median length of stay of 21 days versus 11 days for males (P =.001). Among female patients, 31/117 (26%) died compared to 12/75 (16%) of male patients (P =.056). Females tended to have a higher SCORTEN, but the difference was not statistically significant (P =.061). Hypertension, chronic obstructive pulmonary disease, and diabetes mellitus were all associated with mortality (P <.001). Black and female patients each represented a seemingly disproportionate percentage of our patients and females had longer lengths of stay. Future studies looking at sex- and race-based differences are needed to better understand these potential disparities. |
| first_indexed | 2024-12-11T18:35:10Z |
| format | Article |
| id | doaj.art-595a41f37a444a40bb1228be9beb90e3 |
| institution | Directory Open Access Journal |
| issn | 2468-9122 |
| language | English |
| last_indexed | 2024-12-11T18:35:10Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Burns Open |
| spelling | doaj.art-595a41f37a444a40bb1228be9beb90e32022-12-22T00:54:46ZengElsevierBurns Open2468-91222022-07-0163110115Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experienceMichael J. Duplisea0Carolyn M. Ziemer1Sarah L. Laughon2Felicia N. Williams3University of North Carolina School of Medicine, 101 Manning Drive Chapel Hill, North Carolina 27599, United States of AmericaDepartment of Dermatology, University of North Carolina School of Medicine, 101 Manning Drive Chapel Hill, North Carolina 27599, United States of AmericaDepartment of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive Chapel Hill, North Carolina 27599, United States of AmericaDepartment of Surgery, University of North Carolina School of Medicine, 101 Manning Drive Chapel Hill, North Carolina 27599, United States of America; North Carolina Jaycee Burn Center, 101 Manning Drive Chapel Hill, North Carolina 27599, United States of America; Corresponding author.Stevens-Johnson syndrome (SJS), toxic-epidermal necrolysis (TEN), and SJS-TEN overlap syndrome form a continuum of rare, life-threatening disease that often warrants immediate and intensive treatment in a burn center. Our objective in this study was to determine factors associated with the prevalence, severity, and mortality in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) admitted to our center. We performed a retrospective analysis of 192 patients admitted to our burn center from 1 January 2009 to 31 December 2019 for SJS/TEN. Severity-of-illness Score for TEN (SCORTEN), length of stay, and inpatient mortality were analyzed. Of 192 patients, 104 (54%) were Black, 117 (61%) were female, and 39 (20%) had a pre-existing psychiatric illness. Overall, 43 (22%) patients died. Female patients had significantly longer lengths of stay, with a median length of stay of 21 days versus 11 days for males (P =.001). Among female patients, 31/117 (26%) died compared to 12/75 (16%) of male patients (P =.056). Females tended to have a higher SCORTEN, but the difference was not statistically significant (P =.061). Hypertension, chronic obstructive pulmonary disease, and diabetes mellitus were all associated with mortality (P <.001). Black and female patients each represented a seemingly disproportionate percentage of our patients and females had longer lengths of stay. Future studies looking at sex- and race-based differences are needed to better understand these potential disparities.http://www.sciencedirect.com/science/article/pii/S2468912222000116Stevens-Johnson syndromeToxic epidermal necrolysisRaceSexDisparityComorbidity |
| spellingShingle | Michael J. Duplisea Carolyn M. Ziemer Sarah L. Laughon Felicia N. Williams Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience Burns Open Stevens-Johnson syndrome Toxic epidermal necrolysis Race Sex Disparity Comorbidity |
| title | Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience |
| title_full | Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience |
| title_fullStr | Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience |
| title_full_unstemmed | Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience |
| title_short | Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience |
| title_sort | characteristics associated with disease prevalence scorten length of stay and mortality in hospitalized sjs ten patients a single center eleven year experience |
| topic | Stevens-Johnson syndrome Toxic epidermal necrolysis Race Sex Disparity Comorbidity |
| url | http://www.sciencedirect.com/science/article/pii/S2468912222000116 |
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