Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease
Abstract Recent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25514-6 |
| _version_ | 1811203906293727232 |
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| author | Mizuki Yagishita Hiroto Tsuboi Yuki Kuroda Tomonori Sawabe Akira Kawashima Fumina Kawashima Nana Uematsu Ryota Sato Taihei Nishiyama Mayu Terasaki Hirofumi Toko Fumika Honda Ayako Ohyama Saori Abe Ayako Kitada Haruka Miki Shinya Hagiwara Yuya Kondo Takayuki Sumida Isao Matsumoto |
| author_facet | Mizuki Yagishita Hiroto Tsuboi Yuki Kuroda Tomonori Sawabe Akira Kawashima Fumina Kawashima Nana Uematsu Ryota Sato Taihei Nishiyama Mayu Terasaki Hirofumi Toko Fumika Honda Ayako Ohyama Saori Abe Ayako Kitada Haruka Miki Shinya Hagiwara Yuya Kondo Takayuki Sumida Isao Matsumoto |
| author_sort | Mizuki Yagishita |
| collection | DOAJ |
| description | Abstract Recent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged < 65 years) and the elderly-onset group (aged ≥ 65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD. |
| first_indexed | 2024-04-12T03:02:48Z |
| format | Article |
| id | doaj.art-595b3e9840a24690a52cdd696d0745d9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T03:02:48Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-595b3e9840a24690a52cdd696d0745d92022-12-22T03:50:36ZengNature PortfolioScientific Reports2045-23222022-12-011211810.1038/s41598-022-25514-6Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s diseaseMizuki Yagishita0Hiroto Tsuboi1Yuki Kuroda2Tomonori Sawabe3Akira Kawashima4Fumina Kawashima5Nana Uematsu6Ryota Sato7Taihei Nishiyama8Mayu Terasaki9Hirofumi Toko10Fumika Honda11Ayako Ohyama12Saori Abe13Ayako Kitada14Haruka Miki15Shinya Hagiwara16Yuya Kondo17Takayuki Sumida18Isao Matsumoto19Department of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaDepartment of Rheumatology, Faculty of Medicine, University of TsukubaAbstract Recent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged < 65 years) and the elderly-onset group (aged ≥ 65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD.https://doi.org/10.1038/s41598-022-25514-6 |
| spellingShingle | Mizuki Yagishita Hiroto Tsuboi Yuki Kuroda Tomonori Sawabe Akira Kawashima Fumina Kawashima Nana Uematsu Ryota Sato Taihei Nishiyama Mayu Terasaki Hirofumi Toko Fumika Honda Ayako Ohyama Saori Abe Ayako Kitada Haruka Miki Shinya Hagiwara Yuya Kondo Takayuki Sumida Isao Matsumoto Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease Scientific Reports |
| title | Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease |
| title_full | Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease |
| title_fullStr | Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease |
| title_full_unstemmed | Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease |
| title_short | Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease |
| title_sort | clinical features and serum cytokine profiles of elderly onset adult onset still s disease |
| url | https://doi.org/10.1038/s41598-022-25514-6 |
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