Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nano...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2023-02-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.14.24 |
| _version_ | 1827997329640128512 |
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| author | Qixiong Lin Yueyou Peng Yanyan Wen Xiaoqiong Li Donglian Du Weibin Dai Wei Tian Yanfeng Meng |
| author_facet | Qixiong Lin Yueyou Peng Yanyan Wen Xiaoqiong Li Donglian Du Weibin Dai Wei Tian Yanfeng Meng |
| author_sort | Qixiong Lin |
| collection | DOAJ |
| description | Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nanotechnology has provided a new approach for biomedicine to overcome these obstacles. Biomimetic nanoparticles exhibit various effects (e.g., homotypic targeting, prolonging drug circulation, regulating the immune system, and penetrating biological barriers) after encapsulation by cancer cell membranes. The sensitivity and specificity of diagnostic methods will also be improved by utilizing the properties of cancer cell membranes. In this review, different properties and functions of cancer cell membranes are presented. Utilizing these advantages, nanoparticles can exhibit unique therapeutic capabilities in various types of diseases, such as solid tumors, hematological malignancies, immune system diseases, and cardiovascular diseases. Furthermore, cancer cell membrane-encapsulated nanoparticles show improved effectiveness and efficiency in combination with current diagnostic and therapeutic methods, which will contribute to the development of individualized treatments. This strategy has promising clinical translation prospects, and the associated challenges are discussed. |
| first_indexed | 2024-04-10T05:26:51Z |
| format | Article |
| id | doaj.art-595bc7ff3d864dc3ab2f1e5c6da88905 |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-04-10T05:26:51Z |
| publishDate | 2023-02-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-595bc7ff3d864dc3ab2f1e5c6da889052023-03-07T13:31:38ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862023-02-0114126227910.3762/bjnano.14.242190-4286-14-24Recent progress in cancer cell membrane-based nanoparticles for biomedical applicationsQixiong Lin0Yueyou Peng1Yanyan Wen2Xiaoqiong Li3Donglian Du4Weibin Dai5Wei Tian6Yanfeng Meng7The Ninth Clinical Medical School of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of General Surgery, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 030024, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nanotechnology has provided a new approach for biomedicine to overcome these obstacles. Biomimetic nanoparticles exhibit various effects (e.g., homotypic targeting, prolonging drug circulation, regulating the immune system, and penetrating biological barriers) after encapsulation by cancer cell membranes. The sensitivity and specificity of diagnostic methods will also be improved by utilizing the properties of cancer cell membranes. In this review, different properties and functions of cancer cell membranes are presented. Utilizing these advantages, nanoparticles can exhibit unique therapeutic capabilities in various types of diseases, such as solid tumors, hematological malignancies, immune system diseases, and cardiovascular diseases. Furthermore, cancer cell membrane-encapsulated nanoparticles show improved effectiveness and efficiency in combination with current diagnostic and therapeutic methods, which will contribute to the development of individualized treatments. This strategy has promising clinical translation prospects, and the associated challenges are discussed.https://doi.org/10.3762/bjnano.14.24cancer cell biomimeticsnanoparticlesprecision medicinetargeted therapytheranostic nanomedicine |
| spellingShingle | Qixiong Lin Yueyou Peng Yanyan Wen Xiaoqiong Li Donglian Du Weibin Dai Wei Tian Yanfeng Meng Recent progress in cancer cell membrane-based nanoparticles for biomedical applications Beilstein Journal of Nanotechnology cancer cell biomimetics nanoparticles precision medicine targeted therapy theranostic nanomedicine |
| title | Recent progress in cancer cell membrane-based nanoparticles for biomedical applications |
| title_full | Recent progress in cancer cell membrane-based nanoparticles for biomedical applications |
| title_fullStr | Recent progress in cancer cell membrane-based nanoparticles for biomedical applications |
| title_full_unstemmed | Recent progress in cancer cell membrane-based nanoparticles for biomedical applications |
| title_short | Recent progress in cancer cell membrane-based nanoparticles for biomedical applications |
| title_sort | recent progress in cancer cell membrane based nanoparticles for biomedical applications |
| topic | cancer cell biomimetics nanoparticles precision medicine targeted therapy theranostic nanomedicine |
| url | https://doi.org/10.3762/bjnano.14.24 |
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