Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission.
A mathematical model that simulates malaria transmission under the influence of transgenic mosquitoes refractory to malaria is presented in this paper. The zygosity of transgenic mosquitoes is taken into account and, consequently, the total population of mosquitoes is comprised of wild type and hete...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0285000 |
| _version_ | 1797828116234633216 |
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| author | Ana Paula Wyse Antonio José Boness Dos Santos Juarez Dos Santos Azevedo Aline Costa de Meneses Victor Matheus Da Cunha Santos |
| author_facet | Ana Paula Wyse Antonio José Boness Dos Santos Juarez Dos Santos Azevedo Aline Costa de Meneses Victor Matheus Da Cunha Santos |
| author_sort | Ana Paula Wyse |
| collection | DOAJ |
| description | A mathematical model that simulates malaria transmission under the influence of transgenic mosquitoes refractory to malaria is presented in this paper. The zygosity of transgenic mosquitoes is taken into account and, consequently, the total population of mosquitoes is comprised of wild type and heterozygous and homozygous transgenic mosquitoes. These three mosquito varieties interact by mating and competition, and the genetic characteristics of their resulting offspring are in accordance with Mendelian genetics or the mutagenic chain reaction (MCR) technique. Although the incorporation of transgenic mosquitoes into the ecosystem reduces the incidence of malaria, the model also takes into account the importance of completing treatment in individuals with confirmed infection and the imminent risk of increased environmental temperature. |
| first_indexed | 2024-04-09T12:59:07Z |
| format | Article |
| id | doaj.art-595d81a03bb44a1ca72542ce0dff810c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T12:59:07Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-595d81a03bb44a1ca72542ce0dff810c2023-05-13T05:31:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01184e028500010.1371/journal.pone.0285000Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission.Ana Paula WyseAntonio José Boness Dos SantosJuarez Dos Santos AzevedoAline Costa de MenesesVictor Matheus Da Cunha SantosA mathematical model that simulates malaria transmission under the influence of transgenic mosquitoes refractory to malaria is presented in this paper. The zygosity of transgenic mosquitoes is taken into account and, consequently, the total population of mosquitoes is comprised of wild type and heterozygous and homozygous transgenic mosquitoes. These three mosquito varieties interact by mating and competition, and the genetic characteristics of their resulting offspring are in accordance with Mendelian genetics or the mutagenic chain reaction (MCR) technique. Although the incorporation of transgenic mosquitoes into the ecosystem reduces the incidence of malaria, the model also takes into account the importance of completing treatment in individuals with confirmed infection and the imminent risk of increased environmental temperature.https://doi.org/10.1371/journal.pone.0285000 |
| spellingShingle | Ana Paula Wyse Antonio José Boness Dos Santos Juarez Dos Santos Azevedo Aline Costa de Meneses Victor Matheus Da Cunha Santos Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. PLoS ONE |
| title | Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. |
| title_full | Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. |
| title_fullStr | Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. |
| title_full_unstemmed | Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. |
| title_short | Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission. |
| title_sort | mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission |
| url | https://doi.org/10.1371/journal.pone.0285000 |
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