Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease
Abstract Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twenty-first century. Despite an increasing understanding of these diseases, the lack o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03693-0 |
| _version_ | 1797986019729997824 |
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| author | Yifei Chen Fuji Yang Ying Chu Zhihua Yun Yongmin Yan Jianhua Jin |
| author_facet | Yifei Chen Fuji Yang Ying Chu Zhihua Yun Yongmin Yan Jianhua Jin |
| author_sort | Yifei Chen |
| collection | DOAJ |
| description | Abstract Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twenty-first century. Despite an increasing understanding of these diseases, the lack of effective treatments remains an ongoing challenge. Mitochondria are key players in intracellular energy production, calcium homeostasis, signaling, and apoptosis. Emerging evidence shows that mitochondrial dysfunction participates in the pathogeneses of metabolic diseases. Exogenous supplementation with healthy mitochondria is emerging as a promising therapeutic approach to treating these diseases. This article reviews recent advances in the use of mitochondrial transplantation therapy (MRT) in such treatment. |
| first_indexed | 2024-04-11T07:27:28Z |
| format | Article |
| id | doaj.art-595f2af648c84e80ab83cd1e80f2a31a |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T07:27:28Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-595f2af648c84e80ab83cd1e80f2a31a2022-12-22T04:37:02ZengBMCJournal of Translational Medicine1479-58762022-10-0120111610.1186/s12967-022-03693-0Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver diseaseYifei Chen0Fuji Yang1Ying Chu2Zhihua Yun3Yongmin Yan4Jianhua Jin5Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Department of Oncology, Wujin Hospital Affiliated With Jiangsu University (The Wujin Clinical College of Xuzhou Medical University)Abstract Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twenty-first century. Despite an increasing understanding of these diseases, the lack of effective treatments remains an ongoing challenge. Mitochondria are key players in intracellular energy production, calcium homeostasis, signaling, and apoptosis. Emerging evidence shows that mitochondrial dysfunction participates in the pathogeneses of metabolic diseases. Exogenous supplementation with healthy mitochondria is emerging as a promising therapeutic approach to treating these diseases. This article reviews recent advances in the use of mitochondrial transplantation therapy (MRT) in such treatment.https://doi.org/10.1186/s12967-022-03693-0DiabetesExtracellular vesiclesMitochondrial transferNonalcoholic fatty liver diseaseObesity |
| spellingShingle | Yifei Chen Fuji Yang Ying Chu Zhihua Yun Yongmin Yan Jianhua Jin Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease Journal of Translational Medicine Diabetes Extracellular vesicles Mitochondrial transfer Nonalcoholic fatty liver disease Obesity |
| title | Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease |
| title_full | Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease |
| title_fullStr | Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease |
| title_full_unstemmed | Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease |
| title_short | Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease |
| title_sort | mitochondrial transplantation opportunities and challenges in the treatment of obesity diabetes and nonalcoholic fatty liver disease |
| topic | Diabetes Extracellular vesicles Mitochondrial transfer Nonalcoholic fatty liver disease Obesity |
| url | https://doi.org/10.1186/s12967-022-03693-0 |
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