P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction
ATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial cells, and muscle cells. In this review, we descri...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/1/251 |
| _version_ | 1797543222847733760 |
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| author | Sun-Hee Woo Tran Nguyet Trinh |
| author_facet | Sun-Hee Woo Tran Nguyet Trinh |
| author_sort | Sun-Hee Woo |
| collection | DOAJ |
| description | ATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial cells, and muscle cells. In this review, we described the distribution of P2 receptor subtypes in the cardiac cells and their physiological and pathological roles in the heart. So far, the effects of external application of ATP or its analogues, and those of UTP on cardiac contractility and rhythm have been reported. In addition, specific genetic alterations and pharmacological agonists and antagonists have been adopted to discover specific roles of P2 receptor subtypes including P2X4-, P2X7-, P2Y2- and P2Y6-receptors in cardiac cells under physiological and pathological conditions. Accumulated data suggest that P2X4 receptors may play a beneficial role in cardiac muscle function, and that P2Y2- and P2Y6-receptors can induce cardiac fibrosis. Recent evidence further demonstrates P2Y1 receptor and P2X4 receptor as important mechanical signaling molecules to alter membrane potential and Ca<sup>2+</sup> signaling in atrial myocytes and their uneven expression profile between right and left atrium. |
| first_indexed | 2024-03-10T13:42:35Z |
| format | Article |
| id | doaj.art-595fd059af54482e8e02980c32732f2c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:42:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-595fd059af54482e8e02980c32732f2c2023-11-21T02:55:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122125110.3390/ijms22010251P2 Receptors in Cardiac Myocyte Pathophysiology and MechanotransductionSun-Hee Woo0Tran Nguyet Trinh1Laboratory of Pathophysiology, College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaLaboratory of Pathophysiology, College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial cells, and muscle cells. In this review, we described the distribution of P2 receptor subtypes in the cardiac cells and their physiological and pathological roles in the heart. So far, the effects of external application of ATP or its analogues, and those of UTP on cardiac contractility and rhythm have been reported. In addition, specific genetic alterations and pharmacological agonists and antagonists have been adopted to discover specific roles of P2 receptor subtypes including P2X4-, P2X7-, P2Y2- and P2Y6-receptors in cardiac cells under physiological and pathological conditions. Accumulated data suggest that P2X4 receptors may play a beneficial role in cardiac muscle function, and that P2Y2- and P2Y6-receptors can induce cardiac fibrosis. Recent evidence further demonstrates P2Y1 receptor and P2X4 receptor as important mechanical signaling molecules to alter membrane potential and Ca<sup>2+</sup> signaling in atrial myocytes and their uneven expression profile between right and left atrium.https://www.mdpi.com/1422-0067/22/1/251cardiac myocyte functionP2X receptorsP2Y receptorsextracellular ATPmechanical signalingpathohysiological roles |
| spellingShingle | Sun-Hee Woo Tran Nguyet Trinh P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction International Journal of Molecular Sciences cardiac myocyte function P2X receptors P2Y receptors extracellular ATP mechanical signaling pathohysiological roles |
| title | P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction |
| title_full | P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction |
| title_fullStr | P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction |
| title_full_unstemmed | P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction |
| title_short | P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction |
| title_sort | p2 receptors in cardiac myocyte pathophysiology and mechanotransduction |
| topic | cardiac myocyte function P2X receptors P2Y receptors extracellular ATP mechanical signaling pathohysiological roles |
| url | https://www.mdpi.com/1422-0067/22/1/251 |
| work_keys_str_mv | AT sunheewoo p2receptorsincardiacmyocytepathophysiologyandmechanotransduction AT trannguyettrinh p2receptorsincardiacmyocytepathophysiologyandmechanotransduction |