Oxymatrine and cancer therapy
Oxymatrine is a kind of alkaloid extracted from traditional Chinese herb Sophora flavescens Ait. It has been proved to exert various biological activities such as anti-angiogenesis, proliferation-inhibiting, apoptosis-promoting, analgesic-strengthening, and anti-metastasis. The biological activities...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-12-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X15613911 |
| _version_ | 1819103918899068928 |
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| author | WW Lu R Zhang JS Zhu LQ Xia J Zhang |
| author_facet | WW Lu R Zhang JS Zhu LQ Xia J Zhang |
| author_sort | WW Lu |
| collection | DOAJ |
| description | Oxymatrine is a kind of alkaloid extracted from traditional Chinese herb Sophora flavescens Ait. It has been proved to exert various biological activities such as anti-angiogenesis, proliferation-inhibiting, apoptosis-promoting, analgesic-strengthening, and anti-metastasis. The biological activities are related with inhibition of angiogenesis-associated factors, regulation of related signaling pathway and protein expression, synergistic effects with chemotherapy drug, cell cycle arrest and inhibition of voltage-activated K+ channel. In this review, we summarize the recent investigations of oxymatrine in cancer therapy so as to provide references for further study and clinical therapy. |
| first_indexed | 2024-12-22T01:58:06Z |
| format | Article |
| id | doaj.art-596085c098d6474b8c00fb0ae5f49ae5 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-22T01:58:06Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-596085c098d6474b8c00fb0ae5f49ae52022-12-21T18:42:43ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2015-12-011310.1177/1721727X15613911Oxymatrine and cancer therapyWW LuR ZhangJS ZhuLQ XiaJ ZhangOxymatrine is a kind of alkaloid extracted from traditional Chinese herb Sophora flavescens Ait. It has been proved to exert various biological activities such as anti-angiogenesis, proliferation-inhibiting, apoptosis-promoting, analgesic-strengthening, and anti-metastasis. The biological activities are related with inhibition of angiogenesis-associated factors, regulation of related signaling pathway and protein expression, synergistic effects with chemotherapy drug, cell cycle arrest and inhibition of voltage-activated K+ channel. In this review, we summarize the recent investigations of oxymatrine in cancer therapy so as to provide references for further study and clinical therapy.https://doi.org/10.1177/1721727X15613911 |
| spellingShingle | WW Lu R Zhang JS Zhu LQ Xia J Zhang Oxymatrine and cancer therapy European Journal of Inflammation |
| title | Oxymatrine and cancer therapy |
| title_full | Oxymatrine and cancer therapy |
| title_fullStr | Oxymatrine and cancer therapy |
| title_full_unstemmed | Oxymatrine and cancer therapy |
| title_short | Oxymatrine and cancer therapy |
| title_sort | oxymatrine and cancer therapy |
| url | https://doi.org/10.1177/1721727X15613911 |
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