Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control
The name porcine reproductive and respiratory syndrome virus (PRRSV) NADC30-like was first coined in 2015. It originated from the NADC30 strain that was introduced into China by importing breeding pigs and has since undergone mutations or recombination, resulting in variant viruses. Following widesp...
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.791313/full |
| _version_ | 1818942772982317056 |
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| author | Ying Yu Qiaoya Zhang Zhi Cao Yan-Dong Tang Dasong Xia Gang Wang Hu Shan |
| author_facet | Ying Yu Qiaoya Zhang Zhi Cao Yan-Dong Tang Dasong Xia Gang Wang Hu Shan |
| author_sort | Ying Yu |
| collection | DOAJ |
| description | The name porcine reproductive and respiratory syndrome virus (PRRSV) NADC30-like was first coined in 2015. It originated from the NADC30 strain that was introduced into China by importing breeding pigs and has since undergone mutations or recombination, resulting in variant viruses. Following widespread outbreaks in China in recent years, these NADC30-like strains have presented major health challenges in swine production systems. Outcomes induced by PRRSV NADC30-like infection are highly variable, ranging from inapparent to severe, depending on the recombination between NADC30 and field PRRSV strains prevalent in swine farms. Vaccines and strict biosecurity measures have been explored to fight this disease; however, current PRRSV commercially modified-live virus vaccines (MLVs) have the potential to revert to virulence and only provide limited or no cross-protection efficacy against NADC30-like strains. PRRSVs will remain an ongoing challenge to the swine industry until safe and effective vaccines or antiviral reagents are developed. |
| first_indexed | 2024-12-20T07:16:45Z |
| format | Article |
| id | doaj.art-5961b9dc021740ffbc0bfb9f95a233c2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T07:16:45Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-5961b9dc021740ffbc0bfb9f95a233c22022-12-21T19:48:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-01-011210.3389/fmicb.2021.791313791313Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and ControlYing Yu0Qiaoya Zhang1Zhi Cao2Yan-Dong Tang3Dasong Xia4Gang Wang5Hu Shan6Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin, ChinaCollege of Veterinary Medicine, Shandong Agricultural University, Taian, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaThe name porcine reproductive and respiratory syndrome virus (PRRSV) NADC30-like was first coined in 2015. It originated from the NADC30 strain that was introduced into China by importing breeding pigs and has since undergone mutations or recombination, resulting in variant viruses. Following widespread outbreaks in China in recent years, these NADC30-like strains have presented major health challenges in swine production systems. Outcomes induced by PRRSV NADC30-like infection are highly variable, ranging from inapparent to severe, depending on the recombination between NADC30 and field PRRSV strains prevalent in swine farms. Vaccines and strict biosecurity measures have been explored to fight this disease; however, current PRRSV commercially modified-live virus vaccines (MLVs) have the potential to revert to virulence and only provide limited or no cross-protection efficacy against NADC30-like strains. PRRSVs will remain an ongoing challenge to the swine industry until safe and effective vaccines or antiviral reagents are developed.https://www.frontiersin.org/articles/10.3389/fmicb.2021.791313/fullPRRSVNADC30-likegenetic diversitypathogenicitycontrol |
| spellingShingle | Ying Yu Qiaoya Zhang Zhi Cao Yan-Dong Tang Dasong Xia Gang Wang Hu Shan Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control Frontiers in Microbiology PRRSV NADC30-like genetic diversity pathogenicity control |
| title | Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control |
| title_full | Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control |
| title_fullStr | Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control |
| title_full_unstemmed | Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control |
| title_short | Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control |
| title_sort | recent advances in porcine reproductive and respiratory syndrome virus nadc30 like research in china molecular characterization pathogenicity and control |
| topic | PRRSV NADC30-like genetic diversity pathogenicity control |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.791313/full |
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