Enoxaparin and Pentosan Polysulfate Bind to the SARS-CoV-2 Spike Protein and Human ACE2 Receptor, Inhibiting Vero Cell Infection

Enoxaparin and Pentosan Polysulfate Bind to the SARS-CoV-2 Spike Protein and Human ACE2 Receptor, Inhibiting Vero Cell Infection

As with many other pathogens, SARS-CoV-2 cell infection is strongly dependent on the interaction of the virus-surface Spike protein with the glycosaminoglycans of target cells. The SARS-CoV-2 Spike glycoprotein was previously shown to interact with cell-surface-exposed heparan sulfate and heparin in...

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Bibliographic Details
Main Authors: Maria Ennemoser, Julia Rieger, Eva Muttenthaler, Tanja Gerlza, Kurt Zatloukal, Andreas J. Kungl
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
SARS-CoV-2
COVID-19
Spike glycoprotein
heparan sulfate
dermatan sulfate
LMW heparin
Online Access:https://www.mdpi.com/2227-9059/10/1/49

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